溃疡性结肠炎相关性疲劳的影响因素分析

Influencing factors of ulcerative colitis-related fatigue

目的探讨溃疡性结肠炎(UC)相关性疲劳的影响因素,为改善患者的疲劳状况,提高生活质量提供依据。方法纳入2017年1月到2018年9月就诊于郑州大学第一附属医院的214例UC患者,根据多维度疲劳量表(MFI-20)评分将其分为阳性组和阴性组。分析UC相关性疲劳的影响因素。结果MFI-20总分为(60.07±8.31)分,两组性别、血红蛋白、焦虑抑郁状态、疾病活动的严重程度比较,差异有统计学意义(均P<0.05)。Logistic回归分析显示,女性、低血红蛋白、焦虑抑郁状态、疾病活动期是UC患者产生疲劳的独立危险因素(均P<0.05)。结论疲劳在UC患者中发生率较高,女性患者、贫血、焦虑抑郁状态、疾病活动期是影响其发生的独立危险因素,通过及早识别、干预可控的危险因素,提高UC患者的生存质量。

Objective To explore the influencing factors of ulcerative colitis(UC)-related fatigue,to provide evidence for improving patients’fatigue and quality of life.Methods A total of 214 patients with UC from Junuary 2017 to September 2018 in the First Affiliated Hospital of Zhengzhou University were enrolled.The patients were divided into positive group and negative group according to multidimensional fatigue inventory-20(MFI-20)score.The influencing factors of UC-related fatigue were analyzed.Results The total score of MFI-20 was 60.07±8.31.Gender,hemoglobin,anxiety and depression,severity of disease activity between the two groups were compared,and the differences were statistically significant(all P<0.05).Logistic regression analysis showed that female,low hemoglobin,anxiety and depression,active stage of disease were independent risk factors for UC-related fatigue(all P<0.05).Conclusion Fatigue is pretty common among patients with UC.Female,low hemoglobin,anxiety and depression,active stage of disease are independent risk factors.Early identification and intervention of the controllable risk factors are helpful to enhance the quality of patients with UC.