血清BNP、TnI及Hcy水平变化对急性肺栓塞患者的病情严重程度及预后的影响

Effect of serum BNP, TnI and Hcy levels on severity and prognosis of acute pulmonary embolism

目的探讨血清B型利钠肽(BNP)、肌钙蛋白I(TnI)及同型半胱氨酸(Hcy)水平变化对急性肺栓塞患者的病情严重程度及预后的影响。方法选择我院于2015年10月至2018年10月期间收治的急性肺栓塞患者124例作为观察对象,根据病情严重程度分为低危组(患者无休克也无心功能不全)61例,中危组(患者无休克仅有心功能不全)39例,高危组(患者同时有休克和心功能不全)24例。另选择同期我院收治的健康体检者50例作为对照组。采用电化学发光双抗体夹心法测定血清BNP含量,采用AXSYM型TnI快速定量检测仪测定血清TnI含量,采用循环酶法检测血清Hcy含量。结果观察组血清BNP、TnI和Hcy水平高于对照组,差异具有统计学意义(P<0.05)。高危组血清BNP、TnI和Hcy水平高于中危组和低危组,且中危组高于低危组,差异具有统计学意义(P<0.05)。死亡组血清BNP、TnI和Hcy水平高于存活组,差异具有统计学意义(P<0.05)。结论急性肺栓塞患者血清BNP、TnI和Hcy水平升高,且有利于病情严重程度和预后的评估,值得临床借鉴。

Objective To investigate the effect of serum B-type natriuretic peptide(BNP),troponin I(TnI)and homocysteine(Hcy)levels on the severity and prognosis of acute pulmonary embolism(APE).Methods 124 patients with acute pulmonary embolism admitted to our hospital from October 2015 to October 2018 were selected as the observation objects.According to the severity of the disease,61 patients were divided into the low-risk group(patients without shock or cardiac insufficiency),39 patients in the medium-risk group(patients without shock and only cardiac insufficiency),and 24 patients in the high-risk group(patients with shock and cardiac insufficiency at the same time).In addition,50 healthy people admitted to our hospital during the same period were selected as the control group.Serum BNP content was determined by electrochemiluminescent double antibody sandwich method,serum Troponin I content was determined by AXSYM rapid quantitative analyzer,and serum Hcy content was detected by cyclic enzyme method.Results Serum BNP,TnI and Hcy levels in the observation group were higher than those in the control group(P<0.05).Serum BNP,TnI and Hcy levels in the high-risk group were higher than those in the middle-risk group and the low-risk group,and those in the middle-risk group were higher than those in the low-risk group(P<0.05).Serum BNP,TnI and Hcy levels in the death group were higher than those in the survival group(P<0.05).Conclusion Serum BNP,TnI and Hcy levels in patients with acute pulmonary embolism are elevated,which is conducive to the assessment of the severity and prognosis of the disease and worthy of clinical reference.