支气管肺泡灌洗液T淋巴细胞亚群及细胞学分型对肺间质病分类的诊断意义

Diagnostic significance of T-lymphocyte subsets and cytological classification of bronchoalveolar lavage fluid in classification of pulmonary interstitial disease

目的评价支气管肺泡灌洗液(BALF)的T淋巴细胞亚群及细胞学分型对不同类型间质性肺部疾病(ILD)的辅助诊断价值。方法选取我院住院治疗间质性肺部疾病患者122例,分析其外周血T淋巴细胞亚群、支气管肺泡灌洗液中T淋巴细胞亚群及细胞学分型的结果对ILD分类诊断的相关性。结果1、COP组外周血CD+4T细胞为76.5±9.3%,高于其他各组。2、IPF组BALF中CD+4T细胞为(69.6±26.1)%,高于CTD-ILD组;COP组BALF中CD+8T细胞达(79.2±15.6)%,高于NSIP组和CTD-ILD组。3、BALF中HP组的中性粒细胞为(31.6±19.9)%,高于COP组和CTD-ILD组;COP组的淋巴细胞为(25.9±15.9)%,高于其他各组;CTD-ILD组的嗜酸性粒细胞为(2.9±2.8)%,高于NISP组。结论外周血CD+4T细胞,BALF中CD+4T细胞、CD+8T细胞及细胞学分型对于ILD的分类诊断有一定临床价值。

Objective To evaluate the diagnostic value of T-lymphocyte subsets and cytological types of bronchoalveolar lavage fluid(BALF)in different types of interstitial lung disease(ILD).Methods 122 patients with interstitial pulmonary disease in our hospital were selected to analyze the correlation of T lymphocyte subsets in peripheral blood,T-lymphocyte subsets and cytological classification results in bronchoalveolar lavage fluid to the classification and diagnosis of ILD.Results 1.CD+4 T cells in peripheral blood of the COP group was 76.5±9.3%,higher than other groups.2.CD+4 T cells in BALF of the IPF group was 69.6±26.1%,higher than the CTD-ILD group.CD+8 T cells in BALF of the COP group was 79.2±15.6%,higher than that of the NSIP group and the CTD-ILD group.3.The neutrophils of the HP group in BALF was 31.6±19.9%,higher than that of the COP group and the CTD-ILD group.The lymphocytes of the COP group in BALF was 25.9±15.9%,higher than other groups.The eosinophils of the CTD-ILD group in BALF were 2.9±2.8%,higher than the NISP group.Conclusion CD+4 T cells in peripheral blood,CD+4 T cells,CD+8 T cells and cytological classification in BALF have certain clinical value in the classification and diagnosis of ILD.