肠道噬菌体组与人体健康

Intestinal phageome and human health

噬菌体作为肠道微生物群落的重要组成部分,自生命初期即定植于肠道,在不同生命时期均以较为稳定的状态存在于人体。目前已知的肠道噬菌体主要是DNA噬菌体,且大多以前噬菌体形式存在。肠道噬菌体可通过多种机制优化其宿主微生物群的结构和组成,并以多种方式直接或间接影响人体的生理状态,其结构变化与多种疾病相关。利用测序方法,能够直接获取噬菌体组信息。本文基于噬菌体组的相关研究,综述了肠道噬菌体组与人体健康相关的研究进展,并对该领域的研究方法和发展方向做出展望。

As an important component of the intestinal microbial community,phage has colonized in the intestinal tract in a relatively stable state in different life stages.The currently known intestinal phages are mainly DNA phages,most of which exist in the form of prophage.The intestinal phageome can optimize the structure and composition of the microbiota through various mechanisms,and its structural changes are related to various diseases.This paper reviews the research progress of intestinal phage group and human health,and prospects the research methods and development direction in this field.