IL-22表达在胰腺癌中的临床意义和预后影响

CLINICAL AND PROGNOSTIC SIGNIFICANCE OF EXPRESSION OF IL-22IN PANCREATIC CANCER

目的:研究IL-22在胰腺癌组织中的表达及临床和预后的意义。方法:采用免疫组织化学法对90例胰腺癌石蜡切片进行IL-22表达的检测,分析IL-22的表达与胰腺癌病人临床病理特征和预后的关系,进一步通过Western-blot对结果进行了验证。结果:胰腺癌组织中IL-22表达与病人的淋巴结转移(P=0.016)及TNM分期(P=0.011)明显相关。高表达IL-22组病人比低表达IL-22病人的中位生存时间更短(P<0.05)。单因素分析显示影响胰腺癌预后的因素为病理分化和IL-22的表达。其中胰腺癌组织中IL-22高表达是胰腺癌独立预后危险因素。结论:IL-22对于预后判断和作为治疗靶点可能具有明显价值。

Objective:To study the clinical and prognostic significance of IL-22 in pancreatic cancer.Methods:To detect the expression of IL-22 in pancreatic cancer tissue by immunohistochemistry and analyze the relationship of IL-22 expression and the clinicalpathological factors and prognosis of pancreatic cancer.Validate the finding by Western-blot.Results:IL-22 expression was obviously related to metastasis of lymph node(P=0.016)and TNM stage(P=0.011).The median survival time was shorter in higher IL-22 expression than that in lower IL-22 expression(P<0.05).Univariate analysis showed that pathological differentiation and IL-22 expression were prognostic factors of pancreatic cancer.High IL-22 expression is the independent prognostic risk factor of pancreatic cancer.Western-blot showed that IL-22 expression in pancreatic cancer tissue was higher than that in other tissue.Conclusion:Clinical testing index and IL-22 expression may be both useful in therapy and prognosis of pancreatic cancer.