不同血液净化模式对终末期肾病患者凝血功能及免疫功能的影响

Effects of Different Blood Purification Modes on Coagulation Function and Immune Function in Patients with End-Stage Renal Disease

目的探讨不同血液净化模式对终末期肾病(ESRD)患者凝血功能及免疫功能的影响。方法选取2017年9月至2018年10月期间我院收治的100例ESRD患者,根据治疗方法的不同分为间歇性透析组(n=40)和持续性透析组(n=60)。两组患者均持续治疗6个月,比较治疗前后的凝血功能及免疫功能。结果治疗后,持续性透析组患者的血小板表面P-选择素、vWF、D-二聚体和FIB水平低于间歇性透析组(P<0.05),CD4+和CD4+/CD8+水平高于间歇性透析组(P<0.05)。结论血液透析可有效改善ESRD患者的凝血功能和免疫系统功能,其中持续性血液透析的改善效果更佳。

Objective To investigate the effects of different blood purification modes on coagulation function and immune function in patients with end-stage renal disease(ESRD).Methods 100 ESRD patients admitted to our hospital from September 2017 to October 2018 were enrolled.Patients were divided into intermittent dialysis group(n=40)and continuous dialysis group(n=60)according to different treatment methods.Both groups were treated for 6 months,and the coagulation function and immune function before and after treatment were compared.Results After treatment,the level of platelet surface P-selectin,vWF,D-dimer and FIB in the continuous dialysis group were lower than those in the intermittent dialysis group(P<0.05),and the levels of CD4+and CD4+/CD8+in the continuous dialysis group were higher than those in the intermittent dialysis group(P<0.05).Conclusions Hemodialysis can effectively improve the coagulation function and immune system function in patients with ESRD,and the improvement effect of continuous hemodialysis is better.