基于肠道菌群探讨中医药防治心血管疾病的作用机制

Action Mechanism of TCM in Preventing and Treating Cardiovascular Diseases Based on Intestinal Flora

越来越多的证据表明,肠道菌群参与了人类的健康维护和疾病发展,包括心血管疾病,如冠心病、高血压、心力衰竭等。中医学中“脾”的生理病理功能的现代生物学基础之一可能是肠道菌群及其代谢产物等产生的作用。系统阐述肠道菌群及其代谢产物在心血管疾病发病机制中的作用,并结合中医理论中“脾胃学说”和“心脾相关”理论,提出中医药调节肠道菌群,可能成为未来心血管疾病中医药研究的新方向。

There is an increasing evidence that the intestinal flora is involved in human health maintenance and disease development,including cardiovascular diseases,such as coronary heart disease,hypertension,and heart failure.The effects of intestinal flora and its metabolism may be one of the modern biological foundations of the physiological and pathological function of Spleen in Chinese medicine.This study put forward that regulating intestinal flora may become the new research direction of cardiovascular disease in Chinese medicine,after systematically describing the role of intestinal flora and its metabolites in the pathogenesis of cardiovascular disease combined with TCM theory of Spleen and Stomach,as well as the relations of Heart and Spleen.