益生菌联合序贯疗法治疗幽门螺杆菌相关性胃炎的临床疗效

Clinical Efficacy of Probiotics Combined with Sequential Therapy in the Treatment of Helicobacter Pylori-associated Gastritis

目的探讨益生菌联合序贯疗法治疗幽门螺杆菌(HP)相关性胃炎的临床疗效。方法选取2015年9月-2018年9月期间该院收治的100例幽门螺杆菌相关性胃炎患者,按照随机数字表法将患者均分为两组,对照组50例采取序贯疗法治疗,观察组50例采取益生菌联合序贯疗法治疗,观察两组患者临床有效率、临床症状评分、HP根除率及不良反应发生率。结果观察组临床有效率(96.00%)比对照组临床有效率(78.00%)更高,差异有统计学意义(χ^2=16.188,P<0.05);观察组HP根除率及不良反应发生率分别为98.00%、8.00%,对照组HP根除率及不良反应发生率分别为70.00%、24.00%,与对照组相比,观察组HP根除率更高,不良反应发生率更低,差异有统计学意义(χ^2=4.762、14.583,P<0.05);治疗前,两组患者临床症状评分差异无统计学意义(t=0.240,P>0.05),治疗1周、2周后观察组临床症状评分为(6.14±1.53)分、(3.18±0.54)分,明显低于对照组(7.89±1.44)分、(4.65±0.73)分,差异有统计学意义(t=5.890、11.448,P<0.05)。结论采取益生菌联合序贯疗法治疗幽门螺杆菌相关性胃炎可有效根除HP,改善患者临床症状,临床疗效显著,且不良反应少,安全性高。

Objective To investigate the clinical efficacy of probiotics combined with sequential therapy in the treat-ment of Helicobacter pylori(HP)-associated gastritis.Methods 100 patients with Helicobacter pylori-associated gastri-tis admitted to our hospital from September 2015 to September 2018 were enrolled.The patients were divided into two groups according to the random number table method,and 50 patients in the control group were treated with sequential therapy.50 patients in the observation group were treated with probiotics and sequential therapy.The clinical efficacy,clinical symptom score,HP eradication rate and adverse reaction rate were observed.Results The clinical effective rate of the observation group(96.00%)was higher than that of the control group(78.00%),the difference was statistically significant(χ^2=16.188,P<0.05).The HP eradication rate and adverse reaction rate of the observation group were 98.00%and 8.00%,the HP eradication rate and the incidence of adverse reactions in the control group were 70.00%and 24.00%,respectively.Compared with the control group,the HP eradication rate was higher in the observation group,and the incidence of adverse reactions was lower,the difference was statistically significant(χ^2=4.762,14.583,P<0.05);Before treatment,there was no significant difference in clinical symptom score between the two groups(t=0.240,P>0.05).After 1 week and 2 weeks of treatment,the clinical symptom scores of the observation group were(6.14±1.53)points and(3.18±0.54)points.Significantly lower than the control group(7.89±1.44)points,(4.65±0.73)points(t=5.890,11.448,P<0.05).Conclusion Probiotics combined with sequential therapy for the treatment of Helicobacter pylori-associated gas-tritis can effectively eradicate HP,improve clinical symptoms,with significant clinical efficacy,less adverse reactions and high safety.