全基因组关联分析在乳酸菌研究中的应用

The Application Prospect of Genome-wide Association Study in Lactic Acid Bacteria Research

乳酸菌是重要的工业用微生物之一,广泛用于食品发酵、医疗保健等领域。乳酸菌也是肠道内的有益微生物,具有改善胃肠道环境,维护肠道菌群平衡的作用。全基因组关联分析的出现为乳酸菌的分离筛选以及溯源、进化研究提供了更为可靠的证据和新的思路。本文简述乳酸菌分子生物学研究的必要性,介绍全基因组关联分析的历史以及在细菌中应用的现状,展望该技术在乳酸菌研究中的应用以及面临的困难和解决方法。

Lactic acid bacteria(LAB)is one of the important industrial microorganisms.And LAB are also beneficial microorganisms in the intestine,which have the effect of improving the gastrointestinal environment and maintaining the balance of intestinal flora.The emergence of genome-wide association study(GWAS)provide more reliable degree of evidence and new ideas for the separation,traceability and evolutionary research for the LAB.This paper briefly describes the necessities of LAB molecular biology research,introduces the history of GWAS and the current situation of its application in bacteria,and looks forward to the application of this technology in LAB research,as well as the difficulties will be encountered in the future and solutions will be provided.