精准医学时代骨肉瘤诊疗的研究进展

Research progress on osteosarcoma treatment in the precision medicine era

随着组学技术和大数据技术的不断发展和成熟,精准医学在肿瘤领域取得了许多引人注目的成果。骨肉瘤多发于儿童和青少年,是最常见的骨骼系统原发性恶性肿瘤。自20世纪70年代至今,手术切除和药物化疗一直是骨肉瘤的主要治疗手段,高度基因异质性是其生存率停滞的主要原因。精准医学以组学等技术为基础,根据患者的生物学特征进行精确的诊断和治疗方案的定制。精准医学的实践有望为骨肉瘤研究及患者生存率提高提供新的契机。本文拟对精准医学在骨肉瘤治疗中的研究进展作一系统综述,并进一步探讨骨肉瘤精准治疗的前景和方向。

With the rapid development of omics and big data technology,there have been multiple achievements with the use of precision medicine for cancer treatment.Osteosarcoma,the most common primary malignant tumor of the skeletal system,primarily occurs in children and adolescents.Since the 1970s,surgical resection and chemotherapy have been the main treatments for osteosarcoma;however,the survival rate for this type of cancer has been stagnant due to high genetic heterogeneity.Precision medicine can provide a precise diagnosis and tailored treatments based on the patients’biological characteristics using techniques such as omics.Therefore,application of precision medicine is promising for studying osteosarcoma and improving patient survival rates.This study aims to systematically review the progress of precision medicine in advancing osteosarcoma treatment.In addition,it discusses the prospects and future direction of osteosarcoma precision treatment.