温阳健脾汤对2型糖尿病患者胰岛β细胞功能及血糖控制的影响

Effect of Wenyang Jianpi Decoction on Function of Islet β-Cell and Blood Glucose Control in Patients with T2DM

目的:探讨温阳健脾汤联合恩格列净对2型糖尿病(T2DM)患者胰岛β细胞功能及血糖控制的影响。方法:选取符合纳入标准的T2DM患者104例,以随机数表法分为治疗组(52例)和对照组(52例)。对照组予以恩格列净治疗,治疗组予以温阳健脾汤联合恩格列净治疗,均治疗12周。对比两组治疗前、治疗12周后血糖[糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)]、胰岛β细胞功能[空腹C肽(FCP)、餐后2 h C肽(2 hPCP)]、胰岛素抵抗指数(HOMA-IR)、空腹胰岛素(FINS)、体质量指数(BMI)水平,并对比两组不良反应发生率。结果:两组治疗前HbA1c、FPG、2 hPG、FCP、2 hPCP、HOMA-IR、FINS、BMI水平相比,差异无统计学意义(P均>0.05);两组治疗12周后HbA1c、FPG、2hPG、HOMA-IR、FINS、BMI水平均较治疗前降低(P<0.05),FCP、2 hPCP水平均较治疗前提高(P<0.05),且治疗组改善幅度大于对照组(P<0.01,P<0.05);治疗组不良反应发生率9.62%(5/52)与对照组11.54%(6/52)相比,差异无统计学意义(P>0.05)。结论:温阳健脾汤与恩格列净联合应用治疗2型糖尿病可改善胰岛β细胞功能,减轻胰岛素抵抗,提高血糖控制效果,降低体质量指数,且具有安全性。

Objective:To investigate the effects of Wenyang Jianpi Decoction combined with Jardiance on function of isletβ-cell and blood glucose control in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 104 patients with T2DM were randomly divided into the study group(n=52)and the control group(n=52).The control group was treated with Jardiance;on which basis,and the study group was also treated with Wenyang Jianpi Decoction.The treatment lasted for 12 weeks.The blood glucose levels,including glycated hemoglobin(HbA1c),fasting blood glucose(FPG)and postprandial 2 h blood glucose(2h PG);the function of isletβcell,such as fasting C peptide(FCP)and postprandial 2 h C peptide(2h PCP);the insulin resistance index(HOMA-IR),fasting insulin(FINS)and body mass index(BMI);and the incidence of adverse reactions were compared between before the treatment and after 12 weeks of the treatment in the two groups.Results:There were no statistical differences in the levels of HbA1c,FPG,2h PG,FCP,2h PCP,HOMA-IR,FINS and BMI between the two groups before the treatment(P>0.05).After 12 weeks of the treatment,the levels of HbA1c,FPG,2 hPG,HOMA-IR,FINS and BMI were decreased,and the levels of FCP and 2h PCP were increased than those before the treatment in the two groups;of which the improvements in the study group were more significant(P<0.01,P<0.05).The incidence of adverse reactions was 9.62%(5/52)in the study group,and it was 11.54%(6/52)in the control group;there was no statistical difference between the two groups(P>0.05).Conclusion:Wenyang Jianpi Decoction combined with Jardiance can improve the function of isletβ-cell,reduce insulin resistance,improve glycemic control,and lower body mass index in the treatment of type 2 diabetes.