利培酮联合碳酸锂治疗急性躁狂症患者的临床效果

Clinical effects of Risperidone combined with Lithium carbonate in treatment of patients with acute mania

目的:探究利培酮联合碳酸锂对急性躁狂症患者的疗效。方法:选择急性躁狂症患者114例,依照随机数字表法分为观察组(57例)和对照组(57例)。对照组采用碳酸锂治疗,观察组在对照组基础上联合利培酮治疗。2周为1个疗程,持续治疗8个疗程后,比较两组患者的治疗总有效率与治疗前后的Bech-Rafaelsen躁狂量表(BRMS)评分、言语记忆测验(HVLT-R)评分、炎症因子(IL-4、TNF-α)水平。结果:治疗8个疗程后,观察组总有效率为96.49%,高于对照组的82.46%,差异具有统计学意义(P<0.05);两组患者的BRMS评分与IL-4、TNF-α水平低于治疗前,且观察组BRMS评分、IL-4、TNF-α水平低于对照组,差异均有统计学意义(P<0.05);两组患者HVLT-R评分高于治疗前,且观察组患者HVLT-R评分高于对照组,差异均有统计学意义(P<0.05)。结论:利培酮联合碳酸锂治疗急性躁狂症的临床效果优于单用碳酸锂的效果,能够有效降低患者BRMS评分与血清炎症因子水平,提高其记忆功能。

Objective:To investigate efficacy of Risperidone combined with Lithium carbonate on patients with acute mania.Methods:114 patients with acute mania were selected and divided into observation group(57 cases) and control group(57 cases) according to the random number table method.The control group was treated with Lithium carbonate,while the observation group was treated with Risperidone on the basis of that of the control group.2 weeks were used as a course of treatment.After 8 consecutive courses of treatment,the total effective rate of the treatment as well as the Bech-Rafaelsen mania scale(BRMS) score,the Hopkins verbal learning test(HVLT-R) score,and the inflammatory factor levels(IL-4,TNF-a) before and after the treatment were compared between the two groups.Results:After 8 courses of treatment,the total effective rate of the observation group was 96.49%,which was higher than that of the control group(82.46%),and the difference was statistically significant(P<0.05).The BRMS scores as well as the IL-4 and TNF-a levels in the two groups after the treatment were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The HVLT-R scores of the two groups after the treatment were higher than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Risperidone combined with Lithium carbonate is superior to single Lithium carbonate in the treatment of the patients with acute mania.It can effectively reduce the patients’ BRMS scores and serum inflammatory factor levels,and improve their memory function.