摘要
蜂毒是蜜蜂工蜂毒腺和副腺分泌的透明液体,蜂毒素是蜂毒的主要活性成分,具有抗肿瘤、免疫调节、抗高血压、抗菌、抗炎作用。总结蜂毒素抗肿瘤的作用机制,发现蜂毒素能抑制肿瘤血管的生成,诱导瘤细胞凋亡,也可直接杀伤瘤细胞,还能增加瘤细胞对放疗的敏感性,同时对机体免疫功能具有增强作用。
Bee venom is a transparent venom secreted by bee venom glands and accessory glands.Melittin is the main active component of bee venom.It has anti-tumor,immune regulation,anti-hypertensive,anti-bacterial and anti-inflammatory effects.The mechanism of action were found that melittin can inhibit the formation of tumor blood vessels,induce tumor cell apoptosis,directly kill tumor cells,increase the sensitivity of tumor cell radiotherapy,and enhance the immune function of the body.
作者
杜晓红
陈艳娥
吴国泰
DU Xiao-hong;CHENG Yan-e;WU Guo-tai(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine,Gansu Province,Lanzhou 730000,China)
出处
《蜜蜂杂志》
2019年第11期12-14,共3页
Journal of Bee
基金
甘肃省高等学校科研项目(2016B-060)
甘肃省中医药管理局科研项目(GZK-2016-005)
关键词
蜂毒素
抗肿瘤
作用机制
melittin
anti-tumor
mechanism of action