原发性卵巢透明细胞癌30例临床病理分析

Primary ovarian clear cell carcinoma: a clinicopathological analysis of 30 cases

目的探讨原发性卵巢透明细胞癌(ovarian clear cell carcinoma,OCCC)的临床病理学特点。方法回顾性分析2010年2月~2018年10月安徽省立医院经妇科手术切除的30例OCCC临床病理资料。根据病理形态是否源于内膜样囊肿(endometrioid cyst,EC)分成EC组和非EC组,并对两组及早期和进展期OCCC临床病理特征进行比较分析,并复习相关文献。结果EC组腹水及腹/盆腔转移的发生率比非EC组显著减少(P=0.003,P=0.008)。此外,EC组FIGO分期为早期的多于非EC组(P=0.066)。两组在年龄、单双侧、最大径、CA125、淋巴结转移及存活方面差异无显著性(P>0.05)。早期OCCC患者腹水、腹/盆腔转移及淋巴结转移发生率明显少于进展期OCCC(P<0.05),与其他临床病理特征无关。结论早期OCCC预后较好。与非EC组相比,起源于EC组的患者预后相对较好。

Purpose To investigate the clinicopathological characteristics of primary ovarian clear cell carcinoma(OCCC).Method Retrospective analysis was performed on the clinicopathological data in 30 cases of OCCC after gynecological surgery in Anhui Provincial Hospital from February 2010 to October 2018.The cases were divided into EC group and non-EC group according to whether it originated from endometrioid cyst in the pathological morphology,and the clinicopathological characteristics of the two groups and the early and progressive OCCC were compared and analyzed.Result The incidence of ascites and abdominal/pelvic metastasis in the EC group was significantly lower than that in the non-EC group(P=0.003,P=0.008).Furthermore,there were more early stage cases of FIGO in the EC group than that in the non-EC group(P=0.066).There were no significant differences between the two groups in age,unilateral and bilateral,maximum diameter,CA125,lymph node metastasis and survival(P>0.05).The incidence of ascites,abdominal/pelvic metastasis and lymph node metastasis in early OCCC patients was significantly lower than that in the advanced stage(P<0.05),and there was no correlation between other clinicopathologic features.Conclusion The prognosis of early OCCC is relatively good.Compared with the non-EC group,the patients in the EC group have better prognosis.