围术期营养治疗在脑膜瘤患者中的应用

Application of perioperative nutritional support in patients with meningioma

目的探讨围术期营养治疗在脑膜瘤患者中的应用效果。方法选取宁夏医科大学总医院神经外科2017年1月至2018年11月行脑膜瘤切除术的患者65例,随机分为两组,试验组32例,对照组33例,试验组采用规范的围术期营养治疗,对照组采用传统治疗。观察术前、术后不同时间点空腹血糖、血清白蛋白、炎症指标差异及住院日、住院费在两组间的差异。结果重复测量设计方差分析结果显示血清白蛋白、白细胞计数组间差异有统计学意义(P<0.05),F值分别为8.450、18.647。两两比较结果显示:两组间空腹血糖、血清白蛋白、白细胞计数随时间的变化不同;试验组术后第3天空腹血糖、术后第3/5/8天白细胞计数较对照组低,术后第1天白蛋白水平较对照组高(P<0.05)。与对照组比较,试验组术后住院天数(13.63±3.82)d vs(16.58±6.60)d和抗生素费用(2,923±562.83)元vs(431.37±104.74)元,两组间差异有显著性统计学意义(P<0.05)。结论围术期营养治疗对维持脑膜瘤患者术后血糖稳定、负氮平衡、预防炎症反应和缩短住院日等方面具有一定的作用。

Objective To investigate the effect of perioperative nutritional therapy in patients with meningioma.Methods 65 patients who underwent meningioma resection from January 2017 to November 2018 were selected and randomly divided into two groups:observation group(n=32)and control group(n=33).To observe and compare the differences of postoperative fasting blood glucose,serum albumin,inflammatory index,hospital stay and hospitalization cost between the two groups.Results The results of repeated analysis of variance showed statistically significant differences in albumin and white blood cell count(P<0.05),with an F value of 8.450 and 18.647.Pairwise comparison results showed that the two groups of fasting blood glucose,serum albumin,white blood cell count,along with the change of time were different.Fasting blood glucose on the third day and white blood cell count on the 3/5/8 day after operation were lower than those of the control group.The albumin level on the first day after the operation was higher than that of the control group(P<0.05).Compared to the control group and the observation group,postoperative hospitalization days(13.63±3.82)d vs(16.58±6.60)d,and antibiotic cost(2,923±562.83)yuan vs(431.37±104.74)yuan,have statistically significant(P<0.05).Conclusion Perioperative nutritional therapy plays a certain role in maintaining negative nitrogen balance in patients with meningioma,preventing inflammatory reaction and shortening hospital stay.