外科原发性肝癌患者生活质量的影响因素分析

Influencing factors of quality of life in surgical patients with primary liver cancer

目的评价外科原发性肝癌患者的生活质量,并研究其影响因素,为临床干预和治疗提供参考。方法采用问卷调查表及肿瘤患者生活质量核心问卷表对2017年1月1日至2018年10月31日间收治于上海瑞金医院肝胆外科的364例原发性肝癌患者进行调查,采用单因素分析法及多元线性回归分析法分析影响肝癌患者生活质量的因素。结果单因素分析结果显示,年龄、文化程度、婚姻状况、营养状况、经济收入、付费方式、肝功能分级等因素对原发性肝癌患者的生活质量有显著影响,差异具有统计学意义(P<0.05)。而性别、治疗方法对肝癌患者的生活质量无明显影响。进一步多元线性回归分析结果显示,文化程度、经济收入、营养状况和肝功能分级与肝癌患者的生活质量得分呈正相关;年龄、肝功能分级与肝癌患者的生活质量得分呈负相关(P<0.05)。结论影响原发性肝癌患者生活质量的因素较多,应针对这些影响因素,采取有针对性的干预措施,或能改善患者生活质量。

Objective To explore the factors affecting the quality of life of surgical patients with primary hepatocellular carcinoma(PHC),and to provide evidence for clinical treatment and life intervention.Methods 364 cases of primary liver cancer admitted to the liver and cholecystectomy of Shanghai Ruijin Hospital between January 1,2017 and October 31,2018 were investigated by questionnaires and EORTC QLQC30.The factors affecting the quality of life of patients with primary liver cancer were analyzed by multiple linear regression analysis.Results Univariate analysis showed that age,education level,marital status,nutritional status,income,payment method,Child-Pugh grading of liver function and other factors had significant impact on the quality of life of patients with primary liver cancer(P<0.05).But sex and treatment methods had no obvious effect on the quality of life of liver cancer patients.Multivariate linear regression analysis showed that the education level,economic income,nutritional status of patients were positively correlated with quality of life score,while age,Child-Pugh grade of liver function were negatively correlated with quality of life score(P<0.05).Conclusion There are many factors affecting the quality of life of patients with hepatocellular carcinoma.In the course of treatment,positive and targeted interventions can effectively improve the quality of life of patients.