应用血清PIVKA-Ⅱ诊断肝细胞癌研究进展

Diagnostic value of serum protein induced by vitamin K absence or antagonist Ⅱ for hepatocellular carcinoma

原发性肝癌(PLC)是我国最常见的恶性肿瘤之一,而早期诊断是对肝癌治疗能否获益的关键。维生素K缺乏或拮抗剂II诱导的蛋白(PIVKA-II)是近年来获得研究者广泛关注的一种新型肿瘤标志物,比甲胎蛋白诊断敏感性高。本文介绍了其在肝癌发病机制研究和临床应用方面的价值。

Primary liver cancer(PLC)is one of the most common malignant tumors in China.Early diagnosis of liver cancer is crucial for the outcome of patients with PLC.Protein induced by vitamin K absence or antagonist II(PIVKA-II)is a new serum tumor marker documented in recent years.It has a diagnostic value for hepatocellular carcinoma,reportedly better than the widely used serum tumor marker alpha-fetoprotein(AFP).In this paper,we reviewed the progress of PIVKA-II in the fundamental research and clinical application.