腹腔镜下子宫肌瘤剔除术对子宫肌瘤患者卵巢功能、氧化损伤及舒适度研究

Study on the Effects of Laparoscopic Myomectomy on Ovarian Function, Oxidative Damage and Comfort in Patients with Uterine Fibroids

目的:评价腹腔镜下子宫肌瘤剔除术对子宫肌瘤患者卵巢功能、氧化损伤及舒适度的影响。方法:回顾性分析2016年1月~2017年12月在某院接受开腹子宫肌瘤剔除术41例(腹式组)及腹腔镜子宫肌瘤剔除术45例(腹腔镜组)患者的临床资料,比较两组的卵巢功能、氧化损伤及舒适度情况。结果:腹腔镜组术中出血量、术后肛门排气时间、住院天数及并发症发生率均显著低于腹式组(P<0.05),而术后5d时的氧化损伤指标(Mb、IMA和MDA)、术后3个月时的卵巢功能指标(E2、FSH和LH)及舒适度均明显优于腹式组(P<0.05)。结论:与传统开腹手术相比,腹腔镜下子宫肌瘤剔除术具有创伤小、并发症少、氧化损伤轻、对卵巢功能影响小、患者舒适度高等优势。

Objective: To evaluate the effect of laparoscopic myomectomy on ovarian function, oxidative damage and comfort in patients with uterine fibroids. Methods: The clinical data of 41 patients(abdominal group) and 45 patients(laparoscopic group) who received laparoscopic myomectomy in a hospital from January 2016 to December 2017 were retrospectively analyzed. Ovarian function, oxidative damage and comfort were compared between the two groups. Results: Intraoperative blood loss, postoperative anal exhaust time, length of stay and incidence of complications in the laparoscopic group were significantly lower than those in the abdominal group(P<0.05). The indexes of oxidative damage(Mb, IMA and MDA), ovarian function(E2, FSH and LH) and comfort at 5 days after operation were significantly better than those of the abdominal group(P<0.05). Conclusion: Compared with traditional laparotomy, laparoscopic myomectomy has the advantages of less trauma, less complications, less oxidative damage, less effect on ovarian function and higher comfort of patients.