儿童呼吸道合胞病毒合并A型流感病毒感染的临床特征分析

Clinical characteristic analysis of respiratory syncytial virus combined with influenza A virus infection in children

目的了解呼吸道合胞病毒(respiratory syncytial virus,RSV)合并季节性A型流感病毒(influenza A virus,inf-A)感染的临床特点。方法选择2010年1月至2016年12月无锡市第二人民医院收治的61例年龄﹤5岁的患儿,31例RSV合并inf-A感染患儿作为混合感染组,30例单纯RSV感染患儿作为RSV感染组。回顾性分析两组患儿的临床特征并进行比较。结果混合感染组平均年龄、发热、呕吐、呼吸困难发生率高于RSV组,咳嗽发生率低于RSV组,差异均有统计学意义(P﹤0.01或P﹤0.05);混合感染组更易发生重症肺炎、心肌损害(P﹤0.05),静脉使用糖皮质激素、平均住院时间高于RSV组,差异均有统计学意义(P﹤0.05或P﹤0.01)。混合感染组C-反应蛋白(C-reactive protein,CRP)﹥40 mg/L的患儿比例高于RSV组,差异有统计学意义(P﹤0.05)。结论RSV合并inf-A感染易发生于较大年龄儿童,更易出现发热、呕吐、腹泻、呼吸困难等症状,尤其重症肺炎的发生率高。

Objective To investigate the clinical characteristics of respiratory syncytial virus(RSV)combined with influenza A virus(inf-A)infection.Methods Sixty-one children whose age were less than 5 years old were selected from the Second People's Hospital of Wuxi from January 2010 to December 2016.Thirty-one cases who were infected by RSV and inf-A were studied as MIX group.Thirty RSV-infected children were selected as RSV group.The clinical characteristics of the two groups were retrospectively analyzed and compared.Results The average age and incidence of fever,vomiting,and dyspnea in the MIX group were higher than that in RSV group,with statistically significant differences(P﹤0.01 or P﹤0.05).The incidence of cough was significantly lower in the MIX group than that in the RSV group(P﹤0.05).Patients of MIX group were more prone to develop severe pneumonia and myocardial injury(P﹤0.05).The rate of intravenous glucocorticoids in the MIX group was higher,and the hospital stay was longer than that in the RSV group.There were all statistical significance(P﹤0.05 or P﹤0.01).The proportion of children with CRP﹥40 mg/L in MIX group was higher than that in the RSV group,with statistical significance(P﹤0.05).Conclusion Infection mixed with RSV and inf-A is prone to occur in the older children,which is more prone to manifests as fever,vomiting,diarrhea,dyspnea and other symptoms,especially severe pneumonia.