山腊梅叶健脾汤治疗AECOPD的疗效及对免疫功能和应激反应的影响

Effect of Shanlameiye Jianpi decoction on immune function and stress response in patients with AECOPD

目的探讨山腊梅叶健脾汤治疗慢性阻塞性肺病急性加重(AECOPD)患者的疗效及对免疫功能和应激反应的影响。方法选取84例AECOPD患者,按照随机数字表法分为观察组和对照组各42例,对照组采取西医常规治疗,观察组在对照组基础上给予山腊梅叶健脾汤,比较两组临床疗效、肺功能、免疫功能及氧化应激水平。结果观察组总有效率明显高于对照组(χ2=4.46,P<0.05);治疗后两组第1秒用力呼气量(FEV1)、最大呼气流速(PEFR)、第1秒用力呼气容积/用力肺活量(FEV1/FVC)较治疗前明显升高(t分别=4.52、2.46、5.38、2.51、8.52、4.45,P均<0.05),且观察组治疗后FEV1、PEFR、FEV1/FVC明显高于对照组(t分别=2.17、2.93、3.38,P均<0.05);治疗后两组CD4+、CD4+/CD8+、丙二醛(MDA)、总抗氧化能力(TAC)、蛋白质羧酸(PC)水平较治疗前明显改善(t分别=11.78、3.49、11.08、2.91、11.11、7.41、-2.23、-6.63、5.66、2.78,P均<0.05),且观察组治疗后CD4+、CD4+/CD8+、MDA、TAC、PC改善程度明显优于对照组(t分别=7.33、6.21、-4.18、2.39、-3.21,P均<0.05)。结论山腊梅叶健脾汤能够提高治疗效果,改善患者肺功能、免疫功能及氧化应激反应。

Objective To investigate the curative effect of Shanlameiye Jianpi decoction in treatment of AECOPD and its effect on immune function and stress response. Methods A total of 84 AECOPD patients were enrolled and divided into observation group(42 cases)and control group(42 cases)according to the random number table.The control group was treated with western medicine,the observation group was given Shanlameiye Jianpi decoction on the basis of the control group.The clinical efficacy,lung function,immune function and oxidative stress level were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group(χ2=4.46,P<0.05).After treatment,FEV1,PEFR and FEV1/FVC were significantly higher than those before treatment(t=4.52,2.46,5.38,2.51,8.52,4.45,P<0.05),and these parameters of the observation group was significantly higher than the control group(t=2.17,2.93,3.38,P<0.05).After treatment,the levels of CD4+,CD4+/CD8+,MDA,TAC and PC in the two groups were significantly improved when compared with that before treatment(t=11.78,3.49,11.08,2.91,11.11,7.41,-2.23,-6.63,5.66,2.78,P<0.05),and the improvement degree of these parameters in the observation group were significantly better than those in the control group(t=7.33,6.21,-4.18,2.39,-3.21,P<0.05). Conclusion Shanlameiye Jianpi decoction can improve the therapeutic effect,lung function,immune function,and oxidative stress response.