中西医结合治疗脾虚湿困型溃疡性结肠炎27例临床观察

Clinical Observation on 27 Cases of Ulcerative Colitis of Spleen Deficiency and Damp-trapped Type Treated by Combination of Traditional Chinese and Western Medicine

目的:观察中西医结合疗法对溃疡性结肠炎患者氧化应激及TAM受体分子的影响。方法:选取溃疡性结肠炎患者53例作为研究对象,随机将其分为对照组26例、观察组27例。两组治疗4周后,对比其各项观察指标的变化。结果:治疗后两组Baron评分、血清超氧化物歧化酶(SOD)、丙二醛(MAD)、双歧杆菌、乳杆菌均较治疗前明显改善(P<0.05);观察组在血清超氧化物歧化酶(SOD)、双歧杆菌、乳杆菌及Mertk的改善程度上优于对照组(P<0.05)。结论:中西医结合治疗脾虚湿困型溃疡性结肠炎,能更好地改善患者氧化应激指标、肠道菌群及TAM家族分子。

Objective To observe the effect of Combining traditional Chinese and western medicine therapy on oxidative stress and TAM receptor molecules in patients with ulcerative colitis.Methords 53 patients with ulcerative colitis were randomly divided into control group(n=26)and observation group(n=27).After 4 weeks of treatment,the changes of the observed indexes were compared between the two groups.Results Baron score,serum superoxide dismutase(SOD),malondialdehyde(MAD),bifidobacteria,and lactobacilli were significantly improved in both groups(P<0.05).The Observation group was superior to the control group in the improvement of serum superoxide dismutase(SOD),bifidobacteria,lactobacilli and Mertk.Conclusion Combined traditional Chinese and western medicine therapycan better improve the oxidative stress index,intestinal flora and TAM family of patients with ulcerative spleen and dampness.