创伤后脓毒症早期预测诊断的研究进展

Research progress in early prediction and diagnosis of post-traumatic sepsis

创伤后脓毒症是以创伤后机体内环境失衡导致多器官功能衰竭为主要特点的一种临床综合症。严重创伤后脓毒症或多器官功能衰竭是近80%的创伤后迟发性死亡的主要原因,因此早发现、早治疗是治疗严重创伤后脓毒症的关键。目前随着分子生物学、基因组学的发展,大量与创伤后脓毒症相关的生物学标志物被发现,如降钙素原、巨噬细胞迁移抑制因子、硫氧还蛋白、可溶性CD14亚型、微小核糖核酸等,由于脓毒症的发病机制复杂多样且存在个体差异,导致了单一的生物标志物难以实现有效诊断及预测,因此可能需要多种生物标志物联合检测实现创伤后脓毒症研究的早发现、早治疗。本文对创伤后脓毒症相关生物标志物进行综述。

Post traumatic sepsis is a clinical syndrome characterized by multiple organ failure caused by the imbalance of the body′s internal environment.As severe post traumatic sepsis or multiple organ failure is the main cause of nearly 80%of post traumatic delayed death,early detection and diagnosis is the key to the treatment of severe post traumatic sepsis.With the development of molecular biology and genomics,a large number of biological markers associated with post traumatic sepsis were found,such as calcitonin original,macrophage migration inhibi tory factor,thioredoxin and soluble CD14 subtype,tiny ribonucleic acid,etc.Yet,the complexity of the pathogen esis of sepsis diverse and individual differences has led to the problem that a single biomarker is difficult to make effective diagnosis and forecast.This means that it requires multiple biomarkers combined to achieve the post trau matic sepsis early discovery,early treatment.Upon this background,this article reviews the biomarkers related to post traumatic sepsis.