摘要
HBV感染与胆汁酸存在密切的关系。近年研究表明,HBV感染通过胆汁酸转运蛋白和介导肝损伤参与调节胆汁酸代谢,胆汁酸通过法尼醇X受体改变HBV生物合成。综述了HBV感染与胆汁酸关系的研究进展,以及胆汁酸在HBV相关肝病诊治中的作用,以期为HBV感染的临床诊治提供新思路。
Hepatitis B virus(HBV)infection is closely associated with bile acid.Recent studies have shown that HBV infection is involved in the regulation of bile acid metabolism through bile acid transporters and mediation of liver injury,and bile acid changes HBV biosynthesis through FXR.This article reviews the research advances in the association between HBV infection and bile acid and the role of bile acid in the diagnosis and treatment of HBV-related liver diseases,so as to provide new ideas for the clinical diagnosis and treatment of HBV infection.
作者
李硕
李志国
叶永安
LI Shuo;LI Zhiguo;YE Yong’an(Department of Gastroenterology,Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第11期2561-2564,共4页
Journal of Clinical Hepatology
基金
国家科技重大专项“十三五”课题(2018ZX10725-505-001)
关键词
乙型肝炎病毒
胆酸类
代谢
诊断
hepatitis B virus
cholic acids
metabolism
diagnosis
