摘要
基于多喷头生物3D打印系统和溶芯支撑法,运用超低温打印技术,以胶原为管壁材料,水凝胶F127为溶芯材料构建复合管腔结构,经过京尼平溶液交联及冻干处理后将支架浸泡在1℃的去离子水中以去除溶芯材料,从而获得胶原管腔支架结构;同时探究了以明胶/海藻酸钠为管壁结构,明胶材料为溶芯的管结构制备技术,实验证明明胶作为溶芯材料制备管结构的可行性。制备出了具有较好结构及力学性能的胶原和明胶/海藻酸钠管腔支架结构。该多喷头生物3D打印系统以溶芯工艺的方法,在构建管腔型生物结构方面具有很好的效果,为临床及再生医学提供了重要的制造工艺基础。
This syudy is based on the multi-nozzle biological 3D printing system and the solvus.The composite tube structure is constructed by using the ultra-low temperature printing technique,the collagen as the wall material and the hydrogel F127 as the core material.After the solution is crosslinked and freeze-dried,the stent is immersed in deionized water at 1℃to remove the core material.The structure of the collagen lumen is obtained.The technique of gelatin/sodium alginate as the wall structure and gelatin is used as the core.The feasibility of the gelatin regards as a core material for the preparation of tube structure.The structures of collagen and gelatin/alginate lumen stent with good structural and mechanical properties are prepared.The multi-nozzle biological 3D printing system has a good effect in the construction of luminal bio-structure by the method of soldering process,which provides an important manufacturing process base for clinical and regenerative medicine.
作者
王强
郑雄飞
王赫然
慕丽
WANG Qiang;ZHENG Xiong-fei;WANG He-ran;MU Li(Shenyang Ligong University,School of Mechanical Engineering,Liaoning Shenyang110159,China;Shenyang Institute of Automation,Chinese Academy of Sciences,State Key Laboratory of Robotics,Liaoning Shenyang110016,China)
出处
《机械设计与制造》
北大核心
2019年第11期265-268,共4页
Machinery Design & Manufacture
基金
国家自然科学基金(51305438)
国家高技术研究发展计划(863计划,2015AA020312)
关键词
生物3D打印
多喷头
管腔结构
溶芯材料
Biological 3D Printing
Multi-Nozzle
Lumen Structure
Soluble Core Material