苦参桂花汤联合介入化疗治疗晚期结肠癌及其对CCSA2和survivin表达的影响

Clinical observation of KushenGuihua Decoction combined with interventional chemotherapy for advanced colon cancer and its effect on expressions of CCSA2 and survivin

目的:探讨苦参桂花汤联合介入化疗治疗晚期结肠癌的临床效果及其对肿瘤标志物结肠癌特异性抗原2(CCSA2)和生存素(survivin)表达的影响。方法:选取2015年3月至2017年3月诸暨市人民医院就诊的62例晚期结肠癌患者,随机分为观察组(n=31)与对照组(n=31),2组均采用介入化疗方案,观察组在此基础上再给予苦参桂花汤辨证加减,连续观察8周。评价2组患者中医症候的改善情况,以及生活质量评分变化,记录患者的不良反应与生存率,同时检测2组患者肠镜活检肿瘤标志物CCSA2和survivin的表达。结果:经治疗后观察组的中医症候改善情况、总有效率与生活质量评分均优于对照组(P<0.05),观察组的不良反应发生频次更少,生存率更高(P<0.05),且经治疗后实验组CCSA2及survivin表达水平均显著降低。结论:苦参桂花汤联合介入化疗治疗晚期结肠癌能够有效改善患者的中医症状,提高患者的生活质量与生存率,显著降低不良反应的发生率,同时抑制肿瘤标志物CCSA2及survivin的表达。

Objective:To investigate the clinical effect of KushenGuihua Decoction combined with interventional chemotherapy in the treatment of advanced colon cancer and its effect on the expression of colon cancer specific antigen 2(CCSA2)and survivin as tumor markers.Methods:Sixty-two patients with colon cancer in our hospital were randomly divided as experimental group(n=31)and control group(n=31).Based on the treatment with interventional chemotherapy in both groups,the experimental group was given KushenOsmanthus Decoction for 8 weeks.The improvement in traditional Chinese medicine symptoms and changes of life quality scores were evaluated in two groups.Adverse reactions and survival rate of the patients were recorded.Meanwhile,the expression of CCSA2 and survivin in both groups was detected.Results:After treatment,the traditional Chinese medicine symptoms improved;the total effective rate and the life quality score in the experimental group were better than the control group(P<0.05).Moreover,the frequency of adverse reactions in the experimental group was lower than that in the control group(P<0.05)while the survival rate was much higher(P<0.05).The expression levels of CCSA2 and survivin in the experimental group were significantly decreased after treatment.Conclusion:KushenGuihua Decoction combined with interventional chemotherapy can effectively improve the symptoms of patients with advanced colon cancer and the life quality as well.Meanwhile,it can increase the survival rate but reduce the incidence of adverse reactions in patients and inhibit the expression of CCSA2 and survivin as tumor markers.