脂肪组织异常增殖在甲状腺相关眼病中的作用

Effect of abnormal adipose tissue proliferation in thyroid-associated ophthalmopathy

甲状腺相关眼病(TAO)是最常见的眼眶疾病,公认是一种自身免疫性疾病,其发病机制至今尚未完全阐明。TAO可影响患者的外貌及视功能,严重者可导致失明。脂肪组织增殖导致眼眶组织体积增加是TAO的关键病理特征之一。眼眶脂肪组织的增多能够直接导致眶压增高,眼球突出。此外,脂肪组织可作为一种新的内分泌器官,分泌多种脂肪细胞因子、生长因子及蛋白分子等,其中部分因子可能参与了TAO的发病过程。本文旨在从脂肪分化关键蛋白的表达、自噬、眼眶压力、缺氧等方面,综述脂肪组织异常增殖分化在TAO发病过程中的作用。

Thyroid-associated ophthalmopathy(TAO)is the most common orbital disease and is a specific autoimmune disorder,of which the etiology and pathogenesis is still unclear.TAO can affect the appearance and visual function of patients,and severe cases can lead to blindness.Tissue currently considered excessive expansion due to orbital fat is formed of one of the key pathological features TAO.The increase of orbital adipose tissue can directly lead to increased retrobulbar pressures and eyeball protrusion.As a new endocrine organ,adipose tissue can secrete a variety of adipocytokines,growth factors and protein molecules,some of which may be involved in the pathogenesis of TAO.The role of abnormal adipose tissue proliferation of TAO is reviewed from the expression of key proteins of adipose differentiation,autophagy,retrobulbar pressure and hypoxia.