黄连、肉桂配伍与二甲双胍干预奥氮平引起体重增加的药效比较

Comparative study on pharmacological effects of Compatibility of Coptis chinensis, Cinnamon and Metformin on Interfering with Weight Gain from Olanzapine

目的:比较黄连、肉桂配伍与二甲双胍干预奥氮平引起精神分裂症患者体重增加的药效,探寻奥氮平等第二代抗精神病药引起体重增加的更有效干预手段。方法:单一服用奥氮平引起体重增加的精神分裂症患者60例,按门诊号顺序随机分配到黄连与肉桂颗粒配伍+模拟盐酸二甲双胍缓释片组(A组,30例)、盐酸二甲双胍缓释片+模拟黄连与肉桂颗粒配伍(B组,30例)组,治疗12周。治疗基线和治疗第4、8、12周末分别测定两组体重、身高、腰围以及甘油三酯(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterin,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C),计算体重指数(Body Mass Index,BMI)。治疗基线和治疗12周末用阳性和阴性症状量表(the positive and negative syndrome scale,PANSS)评定疗效。结果:治疗基线,两组体重、腰围、BMI和TG、TC、HDL-C、LDL-C以及PANSS总评分水平差异无统计学意义(F=0.354~0.000,P=0.554~0.982);治疗12周末,两组体重、腰围、BMI、TG、TC、LDL-C水平较治疗基线均显著降低(t=41.213~3.217,P=0.000~0.003),但A组体重、腰围、BMI和TG水平均显著低于B组(F=11.280~4.995,P=0.001~0.026);治疗第12周末,两组PANSS总评分差异无统计学意义(F=0.040,P=0.843)。结论:黄连与肉桂配伍干预奥氮平引起体重增加的效果显著优于二甲双胍。

Objective To compare the Pharmacological effects of Compatibility of Coptis chinensis, cinnamon and metformin on interfering with weight gain from olanzapine in patients with schizophrenia, and to explore a more effective method on interfering with weight gain from olanzapine and other second-generation antipsychotics. Methods A total of 60 schizophrenic patients who took olanzapine alone were allocated to compatibility of coptis chinensis and cinnamon particles in combination with sham sustained-release metformin hydrochloride tablets(A group, n=30) group or sustained-release metformin hydrochloride tablets in combination with compatibility of sham coptis chinensis and sham cinnamon particles(B group, n=30) group according to their outpatient number order. The patients were treated for 12 weeks. At baseline, 4 st, 8 nd and 12 th weekend the body weight, height, waist circumference, and triglyceride(TG), total cholesterol(TC), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C) were measured. In addition, the body mass index(BMI). At baseline, and 12 th weekend the psychiatric symptoms were assessed with the Scale for the positive and negative syndrome scale(PANSS).Results There were no significant differences in the levels of body weight, waist circumference,(BMI), and TG, TC, HDL-C, LDL-C, and total score of PANSS scale between the two groups at baseline(F=0.354~0.000, P=0.554~0.982). At 12 th weekend the levels of body weight, waist circumference, BMI, and TG, TC, LDL-C in both groups were remarkably lower than those at the baseline(t=41.213~3.217,P=0.000~0.003), and the levels of body weight, waist circumference, BMI and TG in group A were significantly lower than those in group B(F=11.280-4.995, P=0.001~0.026). At 12 th weekend there was no significant difference in total score of PANSS scale between the two groups(F=0.040,P=0.843). Conclusion The effect of compatibility of Coptis chinensis and Cinnamon on Interfering with Weight Gain from Olanzapine was significantly better than that of metformin.