不同动物髓样分化因子88基因的功能研究及应用

Progress on Functions and Application of Myeloma Differentiation Factor88 Gene in Animals

髓样分化因子88(myeloid differentiation factor88,MyD88)作为Toll样受体信号通路中的关键转接分子,在多种疾病的发生和免疫调控中发挥重要作用。论文就Toll样受体信号通路中MyD88的结构、表达、免疫调控功能、单核苷酸多态性位点、与动物肠道疾病发病机制研究的相关性及其应用进行综述。

Myeloid differentiation factor 88(MyD88)is a key transit molecule in Toll-like receptors(TLRs)signaling pathway and plays an important role in the occurrence of various diseases and immune regulation.This article reviewed the relationship between the structure and function of MyD88 in Toll-like receptor signaling pathways and the relationship between the intestinal inflammation in animals and its potential application value.