中国组织工程领域2013至2018年国家自然科学基金资助项目分析

Analysis of programs on tissue engineering funded by the National Natural Science Foundation of China between 2013 and 2018

背景:组织工程是再生医学分支下的一个重要方向,具有交叉学科特性,起到修复、维持或改善受损器官与组织功能的作用,受到生物医学领域重视。国家自然科学基金长期对组织工程领域的基础研究进行资助,其资助项目情况可以在一定程度上反映学科发展态势。目的:分析并展示国家自然科学基金对组织工程基础研究的资助情况和学科发展态势。方法:以国家自然科学基金网络信息系统为来源检索2013至2018年间获得资助的组织工程相关项目,利用Excel和Bibexcel对批准年度、项目名称、批准金额、依托单位、资助类别、关键词等内容进行统计分析。结果与结论:近6年来国家自然科学基金对组织工程基础研究资助力度有所减弱,资助项目主要来自生命科学部和医学科学部,项目类型以面上项目和青年科学基金项目为主;获资助项目的依托单位以高校为主,研究实力较强机构研究范围较广,可获得多个分支领域的项目资助;骨和软骨、血管与心脏、口腔、神经和皮肤方向的研究项目较多,血管化、微环境、间充质干细胞、水凝胶、3D打印、定向分化等是研究的热点主题。

BACKGROUND:Tissue engineering as an important branch of regenerative medicine has interdisciplinary characteristics and plays a role in repairing,maintaining or improving the function of damaged organs and tissues,which is highly valued in the biomedical field.The National Natural Science Foundation of China has supported basic research on tissue engineering for years,and the funded programs can reflect the discipline development to some extent.OBJECTIVE:To analyze the information of China tissue engineering funding programs and illustrate its development status and trend.METHODS:Internet-Based Science Information System developed by the National Natural Science Foundation of China was used as a source to retrieve tissue engineering programs funded between 2013 and 2018.Excel and Bibexcel were used to analyze the project data including award year,program name,approval amount,funded organization,funding mechanism,and keywords.RESULTS AND CONCLUSION:In the past 6 years,the basic research programs of tissue engineering funded by the National Natural Science Foundation of China have reduced slightly.The funded programs are mainly from the Department of Life Sciences and the Department of Health Sciences,and the main funding mechanisms are general program and young scientist funds.Most of the organizations funded are universities or colleges,and some of them with strong research ability and wide research ranges can be funded for their programs involving various fields.Bone and cartilage,blood vessels and heart,oral,nerve and skin tissue engineering are the main sub-fields;vascularization,microenvironment,mesenchymal stem cells,hydrogels,three-dimensional printing,directed differentiation are the hot nesearch topics.