自噬与血管新生相关细胞因子

Autophagy and Angiogenesis-Related Cytokines

血管新生发生于机体多种生理病理过程中,已成为诸多病理过程的标志之一。自噬参与调节机体血管新生。在病变组织中,自噬不仅与血管形成密切相关,而且经调节血管新生向病理组织提供必要的氧与能量。通过抑制自噬可以抑制缺氧、能量缺乏等刺激诱导的血管新生。血管新生过程中相关细胞因子参与调节自噬而影响新生血管的形成。通过二者的作用,既可以促进血管新生,也可抑制血管新生,这种机制在机体生理和病理过程中具有重要的作用。本文从自噬通过血管新生细胞因子促进血管新生以及自噬通过血管新生细胞因子抑制血管新生两个方面概述了自噬在血管新生过程中的作用,为疾病的治疗提供新的思路与方法。

Angiogenesis occurs in many physiological and pathological processes,and has become a common sign of many pathological changes.Autophagy is involved in the formation and regulation of new blood vessels.Autophagy also provides oxygen and energy to pathological tissues during angiogenesis.On one side,decreasing autophagic activity could inhibit angiogenesis induced by hypoxia and insufficient energy.On the other side,relevant cytokines in angiogenesis could affect the formation of new blood vessels by regulating autophagy.The interaction of these two processes can inhibit or promote angiogenesis,thus play an important bilateral role in the physiological and pathological processes.In this paper,both promotion and inhibition roles of autophagy during angiogenesis has been summarized,which helps to outline relative new ideas and methods for the treatment of diseases.