从时辰理论探讨痴呆患者动态脑电图的定量分析

Quantitative Analysis of Dynamic Electroencephalography in Patients with Dementia from Time Theory

目的:基于时辰理论探讨老年痴呆患者动态脑电图的量化指标,为诊断痴呆提供电生理依据。方法:选取33例老年痴呆患者为病例组,另招募30例健康老年人为对照组,进行量表筛查和动态脑电图监测,依据中医时辰理论选取相关时辰的脑电图,比较两组脑电图各导联、位点的功率变化。结果:两组无干扰定标脑电图及辰时、午时、申时、酉时的双侧顶枕α波功率比较,差异有统计学意义(P<0.05),部分位点的θ、δ波功率差异有统计学意义(P<0.01);两组在子时睡眠纺锤波的时限、频率及密度上差异有统计学意义(P<0.05);两组在寅时α波功率和θ、δ波功率上差异均有统计学意义(P<0.05或P<0.01);病例组辰时、午时、申时及酉时各时辰之间α波功率比较,差异无统计学意义(P>0.05)。结论:时辰结合脑电图定量分析,对老年痴呆患者的电生理分析具有一定的辅助诊断意义。脑电图θ、δ波功率增加明显,α波功率下降,子时睡眠纺锤波的时限、频率及密度可以作为老年痴呆患者脑电生理的参考指标。

Objective:To explore the quantitative indicators of dynamic electroencephalography(EEG)in patients with senile dementia on the basis of time theory,so as to provide the electrophysiological basis for the diagnosis of dementia.Methods:Total 33 patients with senile dementia were selected as the patient group,and another 30 healthy elderly patients were recruited as the control group for scale screening and dynamic EEG monitoring.According to TCM time theory,the EEG of the relevant hours was selected to compare the changes in the power of each lead and each point of each hour.Results:The bilateral apical and occipitalαwave powers of no-interference EEG,Chen time,Wu time,Shen time,You time between the two groups had statistically significant differences(P<0.05).There were statistically significant of theθandδwave powers of the EEG on some points(P<0.01).There were statistically significant in the duration,frequency and density of sleep spindles between the patient group and the control group in Zi time(P<0.05).Theα,θandδwave powers in Yin time between the patient group and the control group had statistically significant(P<0.05 or P<0.01),while theαwave powers of the patient group in Chen time,Wu time,Shen time,You time etc.had no statistically significant(P>0.05).Conclusions:Quantitative analysis of EEG combined with time theory had a certain diagnostic significance in the electrophysiological analysis of patients with senile dementia.Theθandδwave powers increasing,αwave power decreasing,the duration,frequency and density of the sleep spindles could be used as a reference index for the electrophysiology of the brain in patients with senile dementia.