牡蛎肉提取物对小鼠抗疲劳和耐缺氧能力的影响

Effects of Oyster Meat Extract on Anti-fatigue Ability and Hypoxia Tolerance in Mice

目的:探讨牡蛎肉提取物对小鼠抗疲劳和耐缺氧能力的影响。方法:分别以高、中、低剂量的牡蛎肉提取物给小鼠连续灌胃,不同剂量的干预时间均有2周和4周两种方案,干预后通过负重游泳实验观察小鼠负重游泳时间和免疫器官指数,常压耐缺氧实验观察小鼠耐缺氧能力,强迫游泳实验观察小鼠运动后肝糖原和血乳酸含量变化。结果:与对照组相比,牡蛎肉提取物干预组小鼠负重游泳时间和缺氧死亡时间显著延长(P<0.05),肝糖原含量增加(P<0.05),血清血乳酸含量降低(P<0.05),免疫器官指数提高(P<0.05),并且小鼠抗疲劳能力随着干预时间的延长和干预浓度的增加而逐渐提高,以4周干预时间效果较好。结论:牡蛎肉提取物可以提高小鼠的抗疲劳能力和耐缺氧能力,增强小鼠的免疫能力。

Objective:To explore the effects of oyster meat extract on the anti-fatigue ability and hypoxia tolerance of mice.Methods:Mice were continuously intragastrically administrated with high,medium and low doses of oyster meat extract.The intervention time of different doses was 2 weeks and 4 weeks.After the intervention,the weight-bearing swimming time and immune organ index was observed by weight-bearing swimming test.The ability of hypoxia tolerance was observed by hypoxia test under ordinary pressure.The changes of liver glycogen and blood lactate content after exercise were observed by forced swimming test.Results:Compared with the control group,the weight-bearing swimming time and hypoxia death time of the oyster meat extract intervention groups were significantly prolonged(P<0.05),the liver glycogen content increased(P<0.05),the serum blood lactate content decreased(P<0.05),the immune organ index increased(P<0.05),and the mice’s anti-fatigue ability improved with the extension of the intervention time and the increase of the intervention concentration.When the intervention time was four weeks,the effect was the best.Conclusions:Oyster meat extract can improve the anti-fatigue ability and hypoxia tolerance of mice,and enhance the immunity of mice.