经颅直流电刺激技术在阿尔茨海默症治疗中的研究进展

The Research Progress of Transcranial Direct Current Stimulation in the Treatment of Alzheimer’s Disease

阿尔茨海默症(AD)是不可逆的神经退行性疾病,严重影响患者的身心健康及日常活动,目前尚不能通过药物和认知训练来有效阻止AD病程。经颅直流电刺激(tDCS)是一种非侵入神经调控技术,安全、经济、耐受性良好,近年来已广泛应用于多种神经退行性疾病的研究。研究发现,tDCS可通过调节突触可触性、参与炎症调控和调节局部血流量等多种途径,改善AD患者的学习记忆和认知功能障碍。因此,tDCS是一种非常具有前景的AD治疗手段。为更好了解和推广tDCS在AD的应用,在此就tDCS在AD的应用现状和作用机制进行综述。

Alzheimer′s disease(AD) is an irreversible neurodegenerative disease that seriously affects the physical and mental health and daily activities of patients. It is currently not possible to effectively prevent the course of AD through drug and cognitive training. Transcranial direct current stimulation(tDCS) is a non-invasive neuromodulation technique that is safe, economical, and well tolerated. It has been widely used in many studies of neurodegenerative diseases in recent years. Studies have found out that tDCS can improve learning and memory and cognitive dysfunction in AD patients by regulating synaptic accessibility, participating in inflammation regulation and regulating local blood flow. Therefore, tDCS is a very promising treatment for AD. In order to better understand and promote the application of tDCS in AD, this paper reviewed the application status and mechanisms of tDCS in AD.