儿童支原体肺炎中医证型与临床表现、化验指标及影像学改变的相关性研究

Correlation between TCM Syndromes of Children′s Mycoplasmal Pneumonia and Clinical Performance,Laboratory Index and Chest Imaging Performance

目的:探讨儿童支原体肺炎中医证型与临床表现、化验指标及影像学改变的相关性。方法:收集102例支原体肺炎患儿的临床资料,包括性别、年龄、入院前病程、住院时间、总病程、发热时间、C反应蛋白(CRP)、血沉及影像学改变,并根据中医辨证标准进行辨证分型;所有患儿入院后均行支原体抗体、CRP、血沉、胸片或胸部CT检查。建立数据库,应用SPSS21.0统计软件分析各项检查指标与中医证型的相关性。结果:儿童支原体肺炎的中医证型中,以痰热闭肺证最多见,其次为风热闭肺证和痰湿闭肺证。其中CRP在风热闭肺证组明显增高,与其他两组比较差异有统计学意义(P<0.05);痰湿闭肺证组患儿发热时间为三组中最短,与其他两组比较差异均有统计学意义(P<0.05);不同中医证型患儿的性别、年龄、入院前病程、住院时间、总病程、抗体滴度及血沉、影像学改变比较差异无统计学意义(P>0.05)。结论:痰热闭肺证、痰湿闭肺证、风热闭肺证是支原体肺炎患儿最常见的中医证型。中医证型不仅与患儿临床表现有相关性,与某些化验指标亦相关。

Objective:To investigate the correlation between TCM syndrome types and clinical manifestations,laboratory indicators and imaging changes in children with mycoplasmal pneumonia. Methods:The clinical data of 102 children with mycoplasmal pneumonia were collected,including gender,age,pre-hospital course,hospitalization time,total course of disease,fever time,C-reactive protein(CRP),erythrocyte sedimentation rate and imaging changes,and dialectical according to TCM syndrome differentiation criteria. Classification;all children were examined for mycoplasma antibodies,CRP,erythrocyte sedimentation,chest X-ray or chest CT after admission. Establish a database and apply SPSS21.0 statistical software to analyze the correlation between various inspection indicators and TCM syndrome types.Results:Among the TCM syndromes of mycoplasmal pneumonia in children,the most common syndrome was the syndrome of heat and cold,followed by the syndrome of wind-heat and closed lung and the syndrome of phlegm-dampness and lung. Among them,CRP was significantly increased in the wind-heat-closed lung syndrome group,which was statistically different from the other two groups(P<0.05). The fever time of the children with phlegm-dampness and lung syndrome was the shortest among the three groups,compared with the other two groups. Statistical differences(P<0.05);there were no significant differences in gender,age,pre-hospital duration,length of hospital stay,total duration of disease,antibody titer,erythrocyte sedimentation rate,and imaging changes in children with different TCM syndromes(P>0.05).Conclusion:The syndrome of heat-clearing and closing lung,phlegm-stagnation and lung-clearing syndrome,and wind-heat-closed lung syndrome are the most common TCM syndromes in children with mycoplasmal pneumonia. TCM syndromes are not only related to the clinical manifestations of children,but also related to certain laboratory indicators.