中药抑制血管紧张素Ⅱ的研究概述

An Overview of Traditional Chinese Herbs on Inhibiting Effects on Angiotensin Ⅱ

血管紧张素Ⅱ(Angiotensin Ⅱ,Ang Ⅱ)是肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)中重要组成物质,具有收缩血管、调节醛固酮分泌等作用。然而在病理状态下,Ang Ⅱ可使RAAS过度激活,造成血压升高、水钠潴留、心肾重要脏器损伤等情况,且抑制Ang Ⅱ分泌的化学药物因高血钾、低血压、咳嗽等不良反应限制了临床应用。而某些中药不但可以抑制Ang Ⅱ分泌还可以在一定程度上减少不良反应的发生,因此本文将重点对具有抑制Ang Ⅱ含量的中药进行综述,旨在为临床用药提供参考。

Angiotensin Ⅱ (Angiotensin Ⅱ,AngⅡ) is an important component in renin-angiotensin-aldosterone system (RAAS),which can contract blood vessels and regulate aldosterone secretion. However,in pathological state,AngⅡ may cause over-activation of RAAS,which results in elevated blood pressure,water-sodium retention and injury of important organs like heart and kidney,and so on. Chemical drugs that inhibit AngⅡ are limited in clinical application because of the adverse reactions such as hyperkalemia,hypotension and cough. On the other hand,Chinese herbs not only can inhibit AngⅡ,but also reduce the occurrence of adverse reactions to a certain extent. In this essay,we will focus on the Chinese herbs which can inhibit the content of AngⅡ,in order to provide reference for clinical medication.