衰老心血管事件链

The aging cardiovascular continuum

动脉粥样硬化心血管事件链即传统的心血管事件链(CCC),即心血管疾病是从危险因素开始,经过一系列步骤到终末期心脏病(特征是心室扩张、心力衰竭和死亡),其基本特征是冠状动脉粥样硬化导致冠状动脉狭窄而引起心肌缺血和心肌梗死。衰老心血管事件链(ACC)解释了衰老特别是血管衰老在心血管疾病发生、发展的作用,ACC基本特征是主动脉近端进行性退化伴动脉扩张和硬化,并对心脏、大脑和肾脏等重要器官产生不良影响。2个事件链既有区别,又有联系,相互补充,比较完整解释心血管事件链的发生与发展。

The atherosclerotic cardiovascular continuum or the conventional cardiovascular continuum(CCC)was first described by Dzau in 2006,describing a series of steps cardiovascular disease undergoes,from risk factors at the beginning to end-stage heart disease(characterized by ventricular dilation,heart failure,and death).The essential features of CCC are myocardial ischemia and myocardial infarction due to coronary artery stenosis,which originates from coronary atherosclerosis.O'Rourke proposed the aging cardiovascular continuum(ACC)in 2010 to explained the role of aging,especially vascular aging,in the development of cardiovascular disease.The continuum encompasses progressive deterioration of the proximal aorta properties with increasing arterial stiffness and dilation,resulting in adverse effects on important organs such as the heart,brain,and kidneys.The two continuums are both distinct and related,complement each other and fully illustrate the occurrence and progression of the cardiovascular continuum.