胰岛素样生长因子-Ⅰ在糖尿病足的表达特征及意义

Expression and Significance of Insulin-like Growth Factor-Ⅰ in Diabetic Foot

目的分析胰岛素样生长因子-Ⅰ在糖尿病足的表达特征及意义。方法选30例糖尿病病足患者皮肤样本(A组)、30例糖尿病患者皮肤样本(B组)、30例非糖尿病患者皮肤样本(C组),将3组皮肤样本浸于10%的甲醛溶液中进行固定。脱水处理后用石蜡进行包埋。切片后用光学显微镜对样本进行观察。结果光学显微镜下三组患者皮肤样本中胰岛素样生长因子-1均呈现阳性表达,但C组的阳性细胞率和表达强度高于A组和B组,B组高于A组,A组阳性细胞率和表达强度最弱,三组患者对比差异有统计学意义(P<0.05)。结论糖尿病足患者皮肤溃烂不止与胰岛素样生长因子-Ⅰ的表达有关。

Objective To analyze the expression and significance of insulin-like growth factor-I in diabetic foot. Methods Thirty skin samples of diabetic foot patients(group A), 30 skin samples of diabetic patients(group B), and 30 non-diabetic skin samples(group C) were selected. Three groups of skin samples were immersed in 10% formaldehyde. Fix in solution. After dehydration treatment, it is embedded in paraffin. After sectioning, the sample was observed with an optical microscope. Results In the skin samples of the three groups under the light microscope, insulin-like growth factor-1 was positively expressed, but the positive cell rate and expression intensity of group C were higher than those of group A and group B. Group B was higher than group A and group A was positive. The cell rate and expression intensity were the weakest, and the difference was significant in the three groups,the difference was statistically significant(P<0.05). Conclusion Skin ulceration in diabetic foot patients is not only related to the expression of insulin-like growth factor-I.