疏风通窍汤联合富马酸卢帕他定治疗过敏性鼻炎临床研究

Shufeng Tongqiao decoction combined with rupatadine fumarate in the treatment of allergic rhinitis

目的:观察疏风通窍汤联合富马酸卢帕他定治疗过敏性鼻炎(AR)的疗效。方法:将70例AR患者纳为研究对象,根据患者就医奇偶数次序,将其均分为联合组与对照组各35例,联合组采用疏风通窍汤配合富马酸卢帕他定治疗,对照组使用富马酸卢帕他定,药物治疗1个月后,比较两组治疗效果。结果:两组治疗后,喷嚏、流涕、鼻塞、鼻痒等临床症状及体征积分均较治疗前显著下降(P<0.05),且联合组患者治疗后各临床症状及体征积分均显著低于对照组(P<0.05);治疗后,两组血清IgE、粉尘螨SIgE、屋尘SIgE、IL-4及鼻腔分泌物EOS水平均较治疗前显著下降(P<0.05),且联合组治疗后以上物质水平均显著低于对照组(P<0.05);两组治疗后血清INF-γ水平较治疗前显著上升(P<0.05),且联合组治疗后血清INF-γ水平显著高于对照组(P<0.05);联合组治疗有效率高于对照组,但组间差异不显著(P>0.05);联合组治疗总有效率高于对照组,但组间差异不显著(P>0.05);两组不良反应无显著性差异(P>0.05)。结论:疏风通窍汤联合富马酸卢帕他定能增强药物抗过敏功效,有效缓解AR临床症状与体征,且药物治疗安全性较高。

Objective:To observe the efficacy of Shufeng Tongqiao decoction combined with rupatadine fumarate in the treatment of allergic rhinitis(AR).Methods:Seventy patients with AR were included in the study.According to odevity of visiting sequence of patients,they were divided into combined group(Shufeng Tongqiao decoction with rupatadine fumarate,n=35)and control group(rupatadine fumarate,n=35).After 1 month of drug treatment,the therapeutic effects were compared between the two groups.Results:After treatment,the scores of clinical symptoms and physical signs of sneezing,runny nose,nasal congestion and nasal itching in the two groups were significantly lower than those before treatment(P<0.05),and the scores of clinical symptoms and physical signs in combined group after treatment were significantly lower than those in control group(P<0.05).After treatment,the levels of serum IgE,dermatophagoides farinae SIgE,house dust SIgE,IL-4 and nasal secretion EOS in the two groups were significantly lower than those before treatment(P<0.05),and the levels of above indexes after treatment in combined group were significantly lower than those in control group(P<0.05).The serum INF-γlevel in the two groups after treatment was significantly higher than that before treatment(P<0.05),and the serum INF-γlevel in combined group after treatment was significantly higher than that in control group(P<0.05).The effective rate of treatment in combined group was higher than that in control group(P>0.05).The total effective rate of treatment in combined group was higher than that in control group(P>0.05).There were no significant differences in the adverse reactions between the two groups(P>0.05).Conclusion:Shufeng Tongqiao decoction combined with rupatadine fumarate can enhance the anti-allergic effects of the drug,and effectively alleviate the clinical symptoms and physical signs of AR,with high safety of drug treatment.