石蒜属植物生物碱类化合物及其构效关系研究进展

Research Progress on Chemical Constituents and Structure-activity Relationship of Alkaloids from Plants of Lycoris Herb.

石蒜属植物因其丰富的生物碱类型及多种药理活性,受到了国内外学者的广泛关注。研究表明,石蒜属植物碱主要含有7类,具有抗肿瘤、抗疟疾、抗AChE、抗菌、抗病毒、抗抑郁症、降血压等多种药理活性。文章对10种石蒜属植物所含生物碱种类、数量、药理作用等研究现状进行综述,并重点关注石蒜属生物碱的结构与药理活性之间的构效关系。

Recently,Lycoris plants have received wide attention of scholars home and abroad,because of its rich in alkaloids types and various pharmacological activities.Researches have shown that Lycoris Herb.alkaloids include seven type,possessing multiple phamocology activities,such as antineoplastic,anti-malaria,anticholinesterase,antibiosis and antiviral.In this paper,we selected 10 species of Lycoris to review the alkaloids types,number of alkaloids,pharmacological effects and some other information.And we focus on the structureactivity relationship the structure and pharmacological activities of Lycoris alkaloids.