AECOPD患者合并肺炎支原体感染情况及对人体免疫功能的影响评价

Evaluation of the Infection of AECOPD Patients with Mycoplasma Pneumoniae and Its Effect on Human Immune Function

目的该次研究分析在慢性阻塞性肺疾病加重期(AECOPD)患者合并肺炎支原体感染后对人体免疫功能的影响。方法该次研究样本从该院慢性阻塞性肺疾病加重期患者中选取100例,研究时间从2017年3月—2018年3月,实验组患者为合并肺炎支原体感染患者,对照组患者为未合并肺炎支原体感染患者。结果实验组患者IgG水平(7.28±2.14)g/L高于对照组患者(1.40±0.51)g/L,IgA水平为(0.87±0.33)g/L低于对照组患者(2.03±0.66)g/L,两组对比差异有统计学意义(χ^2=18.899、11.115;P=0.000、0.000);IgM水平差异无统计学意义(χ^2=0.563;P=0.574)。对比两组细胞因子水平,实验组患者IFN-r水平(15.05±0.71)g/L低于对照组(15.97±0.93)g/L,两组对比差异有统计学意义(χ^2=5.559;P=0.000);两组患者TNF-a、IL-6等指标差异无统计学意义(t=0.621、0.612;P=0.535、0.321)。对比两组患者X线胸片表现,两组患者均有单侧肺炎、双侧肺炎、纹理增粗等表现,两组对比差异无统计学意义(χ^2=1.500、1.449、3.251;P=0.220、0.228、0.071)。对比两组患者临床表现,实验组患者发热41例、咳痰50例症状明显高于对照组患者30例、35例(χ^2=5.876、17.647;P=0.015、0.000),其余指标均差异无统计学意义(χ^2=1.098、0.271、0.122、0.070;P=0.274、0.602、0.726、0.790)。结论在慢性阻塞性肺疾病加重期(AECOPD)患者合并肺炎支原体感染后,其发热咳嗽症状比较明显,并且还容易引起免疫功能紊乱,对IFN-r的分泌进行抑制。

Objective This study analyzes the effects of immunosuppression on patients with chronic obstructive pulmonary disease(AECOPD)after infection with Mycoplasma pneumoniae.Methods The study sample was selected from 100 patients with exacerbations of chronic obstructive pulmonary disease in the hospital.The study time was from March 2017 to March 2018.The experimental group was infected with M.pneumoniae.The control group of patients without M.pneumoniae infection.Results The IgG level(7.28±2.14)g/L in the experimental group was higher than that in the control group(1.40±0.51)g/L,and the IgA level was(0.87±0.33)g/L lower than the control group(2.03±0.66)g/L.There was a statistical difference between the two groups(χ^2=18.899,11.115;P=0.000,0.000);there was no statistical difference in IgM levels(χ^2=0.563;P=0.574).Compared with the cytokine levels of the two groups,the IFN-r level(15.05±0.71)g/L in the experimental group was lower than that in the control group(15.97±0.93)g/L.There was a statistical difference between the two groups(χ^2=5.559;P=0.000).There was no statistical difference between TNF-a and IL-6 in the two groups(t=0.621,0.612;P=0.535,0.321).The chest radiographs of the two groups were compared.The two groups had unilateral pneumonia,bilateral pneumonia,and texture thickening.There was no statistical difference between the two groups(χ^2=1.500,1.449,3.251;P=0.220,0.228,0.071).Comparing the clinical manifestations of the two groups of patients,the experimental group of patients with fever,41 cases,cough 50 cases were significantly higher than the control group of 30 cases,35 cases(χ^2=5.876,17.647;P=0.015,0.000),the remaining indicators are not statistical learning differences(χ^2=1.098,0.271,0.1221,0.070;P=0.274,0.602,0.726,0.790).Conclusion In patients with chronic obstructive pulmonary disease(AECOPD)with M.pneumoniae infection,the symptoms of fever and cough are obvious,and it is easy to cause immune dysfunction and inhibit the secretion of IFN-r.