膝关节经验方治疗风寒湿痹型膝骨关节炎的临床探讨

Clinical Study on the Treatment of Wind-cold and Wet-onset Knee Osteoarthritis with Knee Joint Experience

目的探讨膝关节经验方治疗风寒湿痹型膝骨关节炎(KOA)的临床疗效。方法将2017年10月—2018年10月期间90例风寒湿痹型膝关节骨性关节炎患者分组(随机数字表法)。共分为对照组和观察组两组,每组45例。对照组患者治疗药物为硫酸氨基葡萄糖胶囊以及美洛昔康缓释片,观察组治疗药物为西药加上膝关节经验方剂的联合治疗方案。观察在相同时间内,两组膝关节骨性关节炎的患者在接受不同药物治疗后的总体疗效,对比两组药物治疗发挥作用的时间。记录在接受药物治疗前膝关节功能WOMAC评分分数和膝关节疼痛NRS评分分数,和药物治疗后的两项评分作对比。结果观察组总体疗效为98%,远远高于对照组,组间对比差异有统计学意义(χ^2=13.520,P=0.000<0.05)。观察组膝关节疼痛得以彻底缓解用时为(17.27±1.23)d、膝关节活动度得以恢复用时为(15.89±0.13)d,均短于对照组,两组比较差异有统计学意义(t=21.698、22.015,P=0.000、0.000<0.05)。观察组治疗后膝关节功能WOMAC评分、膝关节疼痛NRS评分优于对照组,两组比较差异有统计学意义(t=8.800、100.833,P=0.000、0.000<0.05)。观察组治疗后腰背冷痛评分、乏力评分、关节僵硬评分、关节疼痛评分、活动受限评分优于对照组,两组比较差异有统计学意义(t=3.448、11.074、11.184、4.845、5.648,P=0.001、0.000、0.000、0.000、0.000<0.05)。结论采用西药与膝关节经验方两种药物结合的方案治疗膝骨性关节炎,有显著的改善病情的效果,能够缓解患者关节疼痛的症状,并且有控制病情发展,逆转关节僵硬活动受限症状、恢复关节活动度。经过试验可知,其效果显著且有较高的安全性,适合临床常规使用,应大力推广。

Objective To investigate the clinical efficacy of knee joint experience in the treatment of wind-cold and wet-onset knee osteoarthritis(KOA).Methods Ninety patients with wind-cold and wet-type knee osteoarthritis were enrolled between October 2017 and October 2018(random number table method).They were divided into two groups,control and observation group,with 45 cases in each group.In the control group,the therapeutic drugs were glucosamine sulfate capsule and meloxicam sustained-release tablets,and the observation group was treated with western medicine plus knee joint experience prescription.The overall efficacy of the two groups of knee osteoarthritis patients after receiving different drug treatments was observed at the same time,and the time of action of the two groups of drug treatments was compared.The WOMAC scores of knee function and the NRS scores of knee joint pain before drug treatment were recorded and compared with the two scores after drug treatment.Results The experiment showed that the overall efficacy of the observation group was 98%,which was much higher than that of the control group,and the difference between the groups was significant(χ^2=13.520,P=0.000<0.05).In the observation group,the knee pain was completely relieved(17.27±1.23)d,and the knee joint activity was restored(15.89±0.13)d,which were shorter than the control group.There was statistical significance between the two groups(t=21.698,217.014,P=0.000,0.000<0.05).The WOMAC score and knee joint pain NRS score of the knee joint function in the observation group were better than those in the control group.There was statistical significance between the two groups(t=8.800,100.833,P=0.000,0.000<0.05).In the observation group,the low back pain score,fatigue score,joint stiffness score,joint pain score,and activity restriction score were superior to the control group after treatment.The two groups were statistically significant(t=3.448,11.074,11.184,4.845,5.648,P=0.001,0.000,0.000,0.000,0.000<0.05).Conclusion The combination of Western medicine and knee joint experience can be used to treat knee osteoarthritis,which can significantly improve the condition of the patient,relieve the symptoms of joint pain,and control the development of the disease,and reverse the joint stiffness,limit symptoms and restore joint mobility.After testing,it has obvious effects and high safety,which is suitable for clinical routine use and should be promoted.