布地奈德雾化吸入联合阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果研究

Clinical Effect of Budesonide Aerosol Inhalation Combined with Azithromycin Sequential Therapy on Children with Mycoplasmal Pneumonia

目的分析布地奈德雾化吸入联合阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果研究。方法选取该院2013年1月—2019年5月收纳的小儿支原体肺炎患儿200例进行分组,对照组97例患儿单纯给予阿奇霉素续贯疗法,研究组103例在对照组治疗基础上联合布地奈德雾化吸入,对比分析两组患儿临床治疗疗效、临床时间指标以及治疗前后FEV1、FEV1/FVC、PEF等差异。结果研究组临床疗效为95.15%(98/103),对照组为87.63%(85/97),组间差异有统计学意义(χ^2=3.593,P<0.05);研究组在肺部啰音消失时间、退热时间、住院时间分别为(4.80±0.91)d、(5.32±1.15)d、(7.11±1.02)d,与对照组差异有统计学意义(t=20.010、7.759、13.093,P<0.05);研究组治疗前FEV1、FEV1/FVC、PEF,差异无统计学意义(P>0.05),治疗后组间差异有统计学意义(t=2.870、7.546、6.389,P<0.05)。结论通过对小儿支原体肺炎患儿实施布地奈德雾化吸入联合阿奇霉素序贯疗法治疗后效果良好,可提高疗效,改善肺功能,加快住院康复,临床上值得应用。

Objective To analyze the clinical effect of budesonide aerosol inhalation combined with azithromycin sequential therapy for children with mycoplasmal pneumonia.Methods A total of 200 children with mycoplasmal pneumonia in the hospital from January 2013 to May 2019 were enrolled.The control group received 97 patients with azithromycin alone.The study group was(103 patients)combined with the control group,with budesonide aerosol inhalation,comparative analysis of clinical treatment efficacy,clinical time indicators and FEV1,FEV1/FVC,PEF and other differences before and after treatment.Results The clinical efficacy of the study group was 95.15%(98/103),and that of the control group was 87.63%(85/97).The difference between the groups was statistically significant(χ^2=3.593,P<0.05).The disappearance time of the lungs in the lungs of the study group,the time of fever and hospitalization were(4.80±0.91)d,(5.32±1.15)d,and(7.11±1.02)d,which were significantly different from the control group(t=20.010,7.759,13.093,P<0.05);there was no statistically significant difference in FEV1,FEV1/FVC and PEF before treatment in two groups(P>0.05).There was statistically significant difference between the two groups after treatment(t=2.870,7.546,6.389,P<0.05).Conclusion The treatment of budesonide inhalation combined with azithromycin sequential therapy in children with mycoplasmal pneumonia in children has a good effect,which can improve the curative effect,improve lung function and speed up hospitalization rehabilitation.It is worthy of clinical application.