扶正解毒汤保留灌肠治疗脓毒血症疗效观察

Clinical Observation on Fuzheng Jiedu Decoction in the Treatment of Sepsis

目的探讨扶正解毒汤保留灌肠治疗脓毒血症的临床疗效。方法选取医院重症监护室(ICU)2018年1月至10月收治的脓毒血症患者48例,按随机数字表法分为对照组与观察组,各24例。两组患者均按个体实际情况予脓毒血症标准西医治疗,观察组患者加用扶正解毒汤保留灌肠。结果治疗后,两组患者的急性生理与慢性健康状况(APACHEⅡ)评分、中医证候评分,血清C反应蛋白(CRP)、白细胞介素6(IL-6)、白细胞介素10(IL-10)水平均明显降低,且观察组明显低于对照组(P<0.05);两组患者治疗期间均无明显不良反应发生。结论西医基础治疗联合中药扶正解毒汤保留灌肠治疗脓毒血症疗效较好,可改善临床症状,降低炎性因子水平,并调节免疫功能。

Objective To investigate the clinical efficacy of retention enema with Fuzheng Jiedu Decoction in the treatment of sepsis.Methods Totally 48 patients with sepsis admitted to ICU Department of our hospital from January to October 2018 were selected and divided into the control group and the observation group according to the random number table method,24 cases in each group.The patients in the two groups were given standard Western medicine treatment for sepsis according to the actual situation of the patients,on this basis,the patients in the observation group were given retention enema with Fuzheng Jiedu Decoction.Results After treatment,the Acute Physiology and Chronic Health Evaluation(APACHE)Ⅱscore,TCM symptom scores,the levels of serum C-reactive protein(CRP),interleukin(IL)-6 and IL-10 in the observation group were significantly lower than those in the control group,and those in the observation group were significantly lower than those in the control group(P<0.05).There were no significant adverse reactions in the two groups during the treatment.Conclusion Western medicine treatment combined with Fuzheng Jiedu Decoction is effective in the treatment of sepsis,which can improve the clinical symptoms,reduce the levels of inflammatory factors and regulate the immune function.