恶性脑胶质瘤术后低分割放疗对患者预后的影响

Effect of Low-segment Radiotherapy on Prognosis of Patients with Malignant Glioma

目的探讨恶性脑胶质瘤术后低分割放疗对患者预后的影响。方法选择60例恶性脑胶质瘤患者作为研究对象,随机将其分为治疗组24例与对照组36例,治疗组术后采取低分割放疗,对照组术后采取常规分割放疗。采用Kaplan-Merier法计算无进展生存率与总生存率,记录不良反应及生活质量。结果治疗组的中位无进展生存期为3.6个月(1.6~8.7个月),对照组的中位无进展生存期为2.3个月(1.0~6.9个月),组间比较差异存在统计学意义(P<0.05)。治疗组存活7例,死亡15例,失访2例,中位生存期为17.4个月(4.2~41.5个月);对照组存活11例,死亡22例,失访3例,中位生存期为16.9个月(3.7~42.8个月),组间比较差异尚未达到统计学意义(P>0.05)。2组均有患者出现急性放射性脑水肿,治疗组3例,对照组4例,组间比较差异尚未达到统计学意义(P>0.05)。2组患者治疗前生活质量评价无差异(P>0.05),治疗后2组的生活质量评价均升高,且治疗组显著高于对照组(P<0.05)。结论恶性脑胶质瘤术后采取低分割放疗可改善患者的生活质量,明显延长患者的无进展生存期,但在总生存期上并未体现出明显优势。

Objective To investigate the effect of low-segment radiotherapy on the prognosis of patients with malignant glioma.Methods 60 patients with malignant glioma were randomly divided into the treatment group(24 cases)and the control group(36 cases).The progression free survival and overall survival rate were calculated by Kaplan-Merier method,and adverse reactions and life quality evaluation were recorded.Results The median progression-free survival was 3.6 months(1.6~8.7 months)in the treatment group and 2.3 months(1.0~6.9 months)in the control group.The difference was statistically significant(P<0.05).The median survival time of the treatment group was 17.4 months(4.2~41.5 months)and that of the control group was 16.9 months(3.7~42.8 months).There were 3 cases in the treatment group and 4 cases in the control group.There was no significant difference between the 2 groups(P>0.05).There was no difference in life quality evaluation between the 2 groups(P>0.05).After treatment,the life quality evaluation of the 2 groups was increased,and the treatment group was significantly higher than the control group(P<0.05).Conclusion Low-fraction radiotherapy after malignant glioma surgery can improve the quality of life of patients and significantly prolong the progression-free survival period of patients,but it does not show an obvious advantage in the overall survival period.