甘油三酯在急性胰腺炎的流行病学及发病机制中的研究现状

Epidemiology and Pathogenesis of Triglyceride in Acute Pancreatitis

急性胰腺炎(acute pancreatitis,AP)是常见的消化系统疾病,其中20%~30%可发展成重症急性胰腺炎。高甘油三酯血症(hypertriglyceride,HTG)是急性胰腺炎的危险因素之一,也与急性胰腺炎的预后有着密切的相关性。近年来,很多回顾性及前瞻性的研究,揭示了不同水平的甘油三酯(triglyceride,TG)对AP临床过程的影响。然而,目前尚无统一明确的TG水平阈值一定能导致AP的发生。有关TG导致AP的发生机制较多,并受基因、代谢、环境和个体差异的影响,但具体机制尚不特别明确,值得进一步探讨。

Acute pancreatitis(AP)is one of digestive disorders,in which 20%~30%may develop into severe acute pancreatitis.Hypertriglyceridemia(HTG)is one of risky factors of pancreatitis,which it is also closely related to the prognosis of AP.Recently,many retrospective and perspective studies have reported an effect of different levels of TG on the clinical course of AP.However,there is still no consensus on a definite threshold of TG level which clearly leads to AP.Pathogenesis of TG leading to AP probably are related to the many factors,which is still not very clear and it may be affected by genes,metabolism,environment and individual differences which needs further research.