前列地尔联合大剂量阿托伐他汀对冠心病患者PCI术后造影剂肾病的影响

Effect of alprostadil combined with high dose atorvastatin on contrast induced nephropathy in patients with coronary heart disease after PCI

目的:探讨前列地尔联合大剂量阿托伐他汀对冠心病患者经皮冠状动脉介入(PCI)术后造影剂肾病(CIN)的影响。方法:选择重庆市开州区人民医院行PCI术的120例冠心病患者,分为空白组(n=40)、对照组(n=40)、试验组(n=40),空白组围术期使用氯化钠注射液静脉滴注,对照组联合阿托伐他汀口服,观察组联合前列地尔治疗。比较三组临床疗效。结果:试验组术后3、7 d时Cr低于对照组,术后1、3、7 d时BUN低于对照组,术后1 d时eGFR高于对照组(P<0.05);三组CIN发生率、不良心血管事件发生率比较差异具有统计学意义(P<0.05),三组死亡率、不良反应总发生率比较无统计学意义(P>0.05)。结论:实施PCI术的冠心病患者中应用前列地尔联合大剂量阿托伐他汀效果显著。

Objective: To investigate the effect of alprostadil combined with high dose atorvastatin on contrast induced nephropathy( CIN) in patients with coronary heart disease after percutaneous coronary intervention( PCI). Methods: A total of 120 cases of coronary heart disease for PCI surgery who received therapy in Chongqing Kaizhou People’s Hospital were selected as research objects,they were divided into blank group( n = 40),control group( n = 40) and experimental group( n = 40),the blank group was treated with intravenous drip of sodium chloride injection in perioperative period,the control group was combined with atorvastatin orally,the observation group was combined with alprostadil intravenous drip. The clinical efficacy was compared between the three groups.Results: Cr of the experimental group was lower than that of the control group at 3 days and 7 days after operation,BUN was lower than that of the control group at 1,3,7 days after operation,and eGFR was higher than that of the control group on the 1 st day after operation. There was a significant difference in the incidence of CIN and adverse cardiovascular events among the three groups,but there was no significant difference in mortality and the total incidence of adverse reactions among the three groups. Conclusion: Alprostadil combined with high dose atorvastatin is effective in patients with coronary heart disease undergoing PCI.