循环脂肪因子水平与川崎病的关系研究

Research on the association between circulating adipokine levels and Kawasaki disease

目的:探索循环脂肪因子水平与急性期川崎病间的关系。方法:对2015-2017年于我院经确诊并收治的共124例急性期川崎病患儿采集外周血液标本,并应用酶联免疫实验(ELISA)的方法检测病理组织中趋化素、网膜素-1、脂联素、TNF-α及IL-1β含量,并比较其在川崎病例、一般性发热及健康儿童间的差异。结果:病例组血清趋化素水平(81.27±56.82)显著高于健康对照组(42.57±11.07)及发热对照组(61.08±21.64)(P<0.05);病例组血清网膜素-1(376.71±123.30)显著低于发热对照组(551.37±202.25);病例组血清脂联素水平(14.97±6.34)明显低于发热对照组(33.82±11.48);川崎病组IL-1β的血清细胞因子水平(13.65±3.15)高于正常对照组(2.49±0.35)(P<0.05)。结论:血清中脂肪因子的变化与急性川崎病的早期炎症和脂质代谢紊乱密切相关。

Objective: To investigate the relationship between adipokines including chemerin,omentin-1,adiponectin and acute Kawasaki disease. Methods: Enzyme-linked immunosorbent( ELISA) was used to detect serum levels of chemerin,omentin-1,adiponectin,and inflammatory cytokines IL-1β and TNF-α in 124 cases of patients diagnosed with Kawasaki disease( KD). In addition,56 cases of children with fever and 61 cases of healthy children were selected as febrile and normal controls. Results: Serum levels of chemerin in KD group( 81. 27 ± 56. 82) were higher than that of both the healthy( 42. 57 ± 11. 07) and the febrile controls( 61. 08 ±21. 64)( P < 0. 05);Circulating omentin-1 levels in Kawasaki disease group( 376. 71 ± 123. 30) were significantly lower than that of febrile control( 551. 37 ± 202. 25)( P < 0. 05),also serum adiponectin levels in Kawasaki disease group( 14. 97 ± 6. 34) reduced obviously compared with the febrile control group( 33. 82 ±11. 48). Serum cytokine levels of IL-1β in Kawasaki disease group( 13. 65 ± 3. 15) were higher than those of normal controls( 2. 49 ± 0. 35)( P < 0. 05). Conclusion: These adipokines are closely associated with the early inflammation and lipid metabolism disorders of acute Kawasaki disease.