ACOS综合征患者血清IL-13和FeNO水平检测及其临床意义

The Expression and Clinical Significance of IL-13 Level and FeNO Concentration in Patients with Bronchial Asthma-Chronic Obstructive Pulmonary Overlapping Syndrome

目的通过对ACOS综合征患者血清IL-13和FeNO水平检测,研究其临床意义,为临床ACOS综合征患者的诊断提供依据。方法选取2016年1月至2018年1月在我院呼吸内科收治的ACOS患者40例为A组、同期收治的慢阻肺患者40例为B组,单纯支气管哮喘患者40例为C组。所有患者均进行肺功能检测及血清IL-13和FeNO水平检测,比较三组患者IL-13及FeNO水平差异,并分析IL-13及FeNO水平与肺功能的相关性。结果血清IL-13水平在ACOS患者中水平最高(292.28±57.54pg/mL),且与肺功能呈负相关。FeNO在支气管哮喘组水平最高(54.87±13.21ppb),其次为ACOS组患者(40.46±15.40ppb),在慢阻肺组最低(20.46±10.60ppb)。血清IL-13与FeNO呈正相关关系。结论血清IL-13与FeNO呈正相关,且与肺功能FEV1、FEV1/FVC呈负相关,FeNO、IL-13对ACOS的诊断具有较高的价值。

Objective To study the clinical significance of serum IL-13 and FeNO levels in patients with ACOS syndrome,and provide evidence for the diagnosis of ACOS syndrome.Methods From January,2016 to January,2018,40 patients with ACOS were selected as group A,40 patients with COPD in the same period as group B,and 40 patients with simple bronchial asthma as group C.All patients were tested for lung function,serum IL-13 level and FeNO concentration.The differences of IL-13 level and FeNO concentration among the three groups were compared,and the correlation between IL-13 level and FeNO concentration and lung function was analyzed.Results The serum level of IL-13 was the highest in ACOS patients(292.287±57.54pg/mL)and was negatively correlated with lung function.FeNO concentration in bronchial asthma group was the highest(54.87±13.21ppb),followed by ACOS group(40.46±15.40ppb),and COPD group was the lowest(20.46±10.60ppb).There was a positive correlation between serum IL-13 and FeNO concentration.Conclusion Serum IL-13 is positively correlated with FeNO concentration,and negatively correlated with lung function indexes FEV1 and FEV1/FVC.FeNO and IL-13 are of high value in the diagnosis of ACOS.