基于群体药动学原理对1例新生儿败血症合并脑膜炎的药学监护

Pharmaceutical Care of A Neonate with Septicemia Complicated with Meningitis Based on Population Pharmacokinetics

目的为临床制定万古霉素个体化给药方案提供参考。方法临床药师运用万古霉素群体药动学模型对1例新生儿败血症合并脑膜炎病例开展个体化给药方案调整和实施药学监护。结果在基于治疗药物的监测和万古霉素群体药动学模型制定的万古霉素静脉注射联合脑室内注射的给药方案下,患儿感染得到有效控制,无不良反应发生。结论临床药师应用群体药动学模型优化万古霉素抗感染治疗方案,协助临床医师制定个体化给药方案。

OBJECTIVE To provide reference for physicians to establish individualized treatment of vancomycin.METHODS Clinical pharmacists applied the the population pharmacokinetic(PPK)model to adjust the dosage of vancomycin and to provide pharmaceutical care for a neonate with septicemia complicated with meningitis.RESULTS The infection in this neonate was effectively controlled following intravenous combined with intraventricular injection of vancomycin based on therapeutic drug monitoring and PPK model,and there were no vancomycin-caused adverse reactions.CONCLUSION Pharmacist can optimize the antiinfective treatment of vancomycin and help physicians to eatabilish the individualized treatment with PPK model.