中性粒细胞胞外诱捕网在脓毒症及肠屏障功能中的研究进展

Progress research of neutrophil extracellular traps in sepsis and intestinal barrier function

脓毒症是导致重症患者死亡最主要的因素之一。中性粒细胞是脓毒症过程中发挥免疫应答主要效应细胞。除发挥趋化和吞噬作用,中性粒细胞还能够释放由双链DNA和镶嵌在DNA上抗菌蛋白组成的中性粒细胞胞外诱捕网(NETs)。脓毒症中持续过度形成的NETs将引起血栓及多器官功能障碍(MOD)的发生。肠道作为MOD的始动器官,脓毒症并发肠道屏障受损是MOD发生的重要原因。NETs与肠屏障损伤密切相关,肠道中过度形成的NETs可引起肠黏膜持续炎症,导致肠功能紊乱。文章主要就NETs在脓毒症及肠道功能中新的研究进展进行综述。

Sepsis is one of the most important factors leading to death in critically ill patients.Neutrophils are the main effector cells that play an immune response during sepsis.In addition to exerting chemotaxis and phagocytosis,neutrophils are also capable of releasing neutrophil extracellular traps(NETs)composed of double-stranded DNA and antibacterial proteins embedded in DNA.The persistent over-formation of NETs in sepsis will cause thrombosis and multiple organ dysfunction(MOD).Gut as the initial organ of MOD,sepsis and intestinal barrier damage is an important cause of MOD.Studies have confirmed that NETs are closely related to intestinal barrier damage,and excessive formation of NETs in the intestine can cause persistent inflammation of the intestinal mucosa,leading to intestinal dysfunction.This article outlines the latest advances in NETs in sepsis and intestinal function,providing new directions for the early diagnosis and treatment of sepsis.